The impact of comorbidity on the survival of postmenopausal women with breast cancer
The impact of comorbidity on the survival of postmenopausal women with breast cancer
复制标题
DOI：
10.1007/s00432-004-0594-3
复制
发表时间：
2004-11-01
影响因子：
3.6
通讯作者：
Katenkamp, D
中科院分区：
文献类型：
--
作者：
Nagel, G;Wedding, U;Katenkamp, D
目的：评估1995-1997年期间合并症对绝经后乳腺癌妇女生存率的影响。方法：采用Satariano和Charlson提出的方法描述合并症的水平。使用考克斯的比例风险模型来探索合并症对全因死亡率的影响。结果：中位随访时间为52个月后，合并症水平的增加与全因死亡率的升高相关。与无合并症的患者相比，Satariano指数1的死亡风险比（HR）为1.2（95% CI：0.8-1.7），Satariano指数大于或等于2的HR为2.3（95% CI：1.5-3.5），Charlson合并症指数的HR分别为1.6和2.1。独立于合并症，治疗模式对生存率有很大影响。合并症水平对绝经后乳腺癌患者3年生存率有影响。结论：需要长期随访来评估这些结果与治疗策略的关系。
Purpose: The aim was to assess the impact of comorbidity on survival of postmenopausal women with breast cancer diagnosis in the period 1995-1997. Methods: The level of comorbidity was described by the methods suggested by Satariano and Charlson. Cox's proportional hazard models were used to explore the impact of comorbidity on all-cause mortality. Results: After a median follow-up time of 52 months, an increasing level of comorbidity was associated with a higher all-cause mortality. Compared to patients without comorbid conditions, the hazard ratio of death (HR) was 1.2 (95% Cl: 0.8-1.7) for Satariano index 1 and HR 2.3 (95% Cl: 1.5-3.5) for Satariano index greater than or equal to2, and HR 1.6 and 2.1 for the Charlson comorbidity index, respectively. Independent of comorbidity, the treatment pattern had a strong impact on survival. The level of comorbidity has an influence on the 3-year survival of postmenopausal women with breast cancer. Conclusions: Long-term follow-up is required to appraise these findings in relation to treatment strategies.