Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells
Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells
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DOI：
10.1073/pnas.1513359112
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发表时间：
2015-09-01
影响因子：
11.1
通讯作者：
Zeng, Mu-Sheng
中科院分区：
文献类型：
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作者：
Xiong, Dan;Du, Yong;Zeng, Mu-Sheng
EBV引起B淋巴瘤和未分化鼻咽癌（NPC）。虽然EBV感染B淋巴细胞的机制已被广泛研究，EBV感染鼻咽上皮细胞（NPEC）的机制的研究最近才通过B淋巴瘤Mo-MLV插入区1同源物（BMI 1）-永生化的NPEC在体外的成功生长和神经纤毛蛋白1表达积极影响EBV糖蛋白B（gB）的发现而得以实现。介导的感染和酪氨酸激酶激活增强BMI 1-永生化NPEC的EBV感染。我们现在发现，即使EBV感染的NPEC以极低的效率作为单层生长（
EBV causes B lymphomas and undifferentiated nasopharyngeal carcinoma (NPC). Although the mechanisms by which EBV infects B lymphocytes have been extensively studied, investigation of the mechanisms by which EBV infects nasopharyngeal epithelial cells (NPECs) has only recently been enabled by the successful growth of B lymphoma Mo-MLV insertion region 1 homolog (BMI1)-immortalized NPECs in vitro and the discovery that neuropilin 1 expression positively affects EBV glycoprotein B (gB)-mediated infection and tyrosine kinase activations in enhancing EBV infection of BMI1-immortalized NPECs. We have now found that even though EBV infected NPECs grown as a monolayer at extremely low efficiency (