Failure in asthma control: reasons and consequences.
Failure in asthma control: reasons and consequences.
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作者：
Braido F
临床研究表明，哮喘控制是一个可以实现的目标。然而，现实生活中的观察表明，很大一部分患者患有症状，并报告生活方式的限制，对患者的生活质量造成相当大的负担。哮喘控制的实现是疾病模式、患者和医生的知识和行为等不同变量之间相互作用的结果。哮喘控制的失败可以被认为是不同变量之间复杂相互作用的结果，例如指南的传播和实施的作用，一些疾病相关因素（即，哮喘中常见合并症的存在，例如胃食管反流病（GERD）、睡眠障碍和阻塞性睡眠呼吸暂停（OSA），以及鼻炎）或患者相关因素（即，坚持治疗、述情障碍和应对策略）。哮喘控制可以通过定制的治疗计划来实现，同时考虑到有助于实现和维持这一目标的因素的复杂性。
Clinical research showed that asthma control is an achievable target. However, real-life observations suggest that a significant proportion of patients suffer from symptoms and report lifestyle limitations with a considerable burden on patient's quality of life. The achievement of asthma control is the result of the interaction among different variables concerning the disease pattern and patients' and physicians' knowledge and behaviour. The failure in asthma control can be considered as the result of the complex interaction among different variables, such as the role of guidelines diffusion and implementation, some disease-related factors (i.e., the presence of common comorbidities in asthma such as gastroesophageal reflux disease (GERD), sleep disturbances and obstructive sleep apnea (OSA), and rhinitis) or patient-related factors (i.e., adherence to treatment, alexithymia, and coping strategies). Asthma control may be reached through a tailored treatment plan taking into account the complexity of factors that contribute to achieve and maintain this objective.