Visual evoked potentials in infants of diabetic mothers: Relations to clinical and metabolic status during pregnancy and delivery
Visual evoked potentials in infants of diabetic mothers: Relations to clinical and metabolic status during pregnancy and delivery
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DOI：
10.1016/j.clinph.2008.12.028
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发表时间：
2009-03-01
影响因子：
4.7
通讯作者：
Napoli, A.
中科院分区：
文献类型：
--
作者：
Brinciotti, M.;Matricardi, M.;Napoli, A.
目的：目的：探讨糖尿病母亲（IDM）婴儿的视觉诱发电位（VEPS）和精神发育与其妊娠和分娩期间临床和代谢数据的关系。方法：对40例2个月大的IDM（男21例，女19例）、24例1型糖尿病母亲、13例妊娠期糖尿病母亲和3例2型糖尿病母亲的VEPS和精神发育（Brunet-Lezine）进行分析。结果：糖尿病患者VEP潜伏期明显长于对照组（O 1波IV = 197.9 ± 35.5 vs 155.3 ± 30.3; P < 0.001; O2波IV = 200.2 ± 33.8 vs 155.6 ± 29.0; P < 0.001）。平均发育商正常。在患有1型糖尿病的糖尿病母亲中，VEP延迟与妊娠期间体重增加有关（r 0.516; P 0.009），妊娠早期空腹血糖（r 0.458：P 0.037），第2天期间的胰岛素需求（r 0.441; P 0.035）和妊娠晚期糖尿病组VEP潜伏期与Apgar评分呈负相关（r = 0.422：P0.039）结论：糖尿病孕妇VEP延迟，可能与妊娠期糖尿病孕妇代谢控制不良及妊娠期糖尿病孕妇分娩并发症有关。意义：IDMS显示VEP可检测到的细微神经生理变化。2009年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To evaluate Visual Evoked Potentials (VEPS) and psychomotor development of infants of diabetic mothers (IDMs) in relation to clinical and metabolic data during pregnancy and delivery.Methods: VEPs and psychomotor development (Brunet-Lezine) were analysed in 40 two-month-old IDMs (21 males, 19 females), 24 from mothers with type-1 diabetes, 13 gestational diabetes, and 3 type-2 diabetes. Normative VEP data were obtained from 63 age matched controls.Results: VEP latencies were significantly longer in IDMs than in controls (O1 wave IV 197.9 +/- 35.5 vs 155.3 +/- 30.3; P < 0.001 : O2 wave IV = 200.2 +/- 33.8 vs 155,6 +/- 29.0; P < 0.001). The mean developmental quotient was normal. In IDMs with type-1 diabetes delayed VEPs were related to increased weight during pregnancy (r 0.516; P 0.009), 1st trimester fasting blood glucose (r 0.458: P 0.037), insulin requirement during the 2nd (r 0.441; P 0.035) and 3rd trimester (r 0.422: P 0.039); in IDMs with gestational diabetes, VEP latency showed negative relation to Apgar scores (r -0.748; P 0.008).Conclusions: IDMs have delayed VEPs, which may possibly be related to poor metabolic control in pregestational diabetes, and to delivery complications in gestational diabetes. Significance: IDMS show subtle neurophysiologic changes detectable by VEPs. 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.