Changes in plasma Brain-derived neurotrophic factor (BDNF) levels induced by methylphenidate in children with Attention deficit-hyperactivity disorder (ADHD)
Changes in plasma Brain-derived neurotrophic factor (BDNF) levels induced by methylphenidate in children with Attention deficit-hyperactivity disorder (ADHD)
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DOI：
10.1016/j.pnpbp.2013.07.018
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发表时间：
2013-12-02
影响因子：
5.6
通讯作者：
Roushan, Zahra Atrkar
中科院分区：
文献类型：
--
作者：
Amiri, Ali;Parizi, Gholamreza Torabi;Roushan, Zahra Atrkar
目的：BDNF可能参与了ADHD的发病机制。我们的目的是确定哌甲酯是否可以诱导血浆BDNF水平的儿童ADHD.Methods的变化：我们评估了血浆BDNF水平在28 ADHD患者（年龄范围-3.5-10岁）之前和之后6周的哌甲酯有效剂量的治疗。然后我们评估了血浆脑源性神经营养因子水平与临床变量的相关性，特别是多动症康纳父母评分量表。结果：根据配对样本T检验，基线时平均血浆BDNF水平为193.06 pg/ml，而终点时平均血浆BDNF水平为271.06 pg/ml，因此显示治疗后情况下的平均血浆BDNF水平显著高于治疗前（t =-3.393，df = 27，p = 0.002）。Pearson相关性检验显示，ADHD患者治疗前血浆BDNF水平与治疗后多动症状的改善呈显著负相关（Pearson相关系数=-0.395，p = 0.037）。此外，我们发现，随着基线血浆BDNF水平的降低，多动症状得到改善。我们建议进行更多的研究，以评估血浆BDNF水平在治疗反应预测和预后中的可能作用。(C)2013 Elsevier Inc. All rights reserved.
Objectives: It has been suggested that BDNF may play a role in the pathogenesis of ADHD. Our aim is to determine whether methylphenidate can induce changes in plasma BDNF levels of children with ADHD.Methods: We assessed levels of plasma BDNF in 28 ADHD patients (age range - 3.5-10 years) before and after 6 weeks treatment with effective dosages of methylphenidate. Then we evaluated the correlation of levels of plasma BDNF with clinical variables, especially ADHD Conner's parents rating scale.Results: According to the paired sample T-test, the mean plasma BDNF level in the baseline was 193.06 pg/ml, whereas 271.06 pg/ml in the end point, thus showing significantly higher mean plasma BDNF levels in the post-treatment situation than in the pretreatment (t = -3.393, df = 27, p = 0.002). Pearson's correlation test revealed that there was also significant negative correlation between levels of BDNF in the plasma of ADHD patients before treatment and improvement in hyperactivity symptoms with treatment (Pearson's correlation = -0.395, p = 0.037).Conclusion: The mean plasma BDNF levels increased after 6 weeks of treatment with methylphenidate. Also, we found an improvement in hyperactivity symptoms with decreasing baseline plasma BDNF levels. We recommend that more studies should be conducted in order to assess the possible roles of plasma BDNF levels in treatment response prediction and prognosis. (C) 2013 Elsevier Inc. All rights reserved.