Role of adult neurogenesis in hippocampal-cortical memory consolidation.
Role of adult neurogenesis in hippocampal-cortical memory consolidation.
复制标题
DOI：
10.1186/1756-6606-7-13
复制
发表时间：
2014-02-19
期刊：
影响因子：
3.6
通讯作者：
Inokuchi K
中科院分区：
文献类型：
--
作者：
Kitamura T;Inokuchi K
获得性记忆最初依赖于海马体（HPC）形成永久记忆。这种海马体对记忆回忆的依赖性随着时间的推移而逐渐衰减，这一过程与对皮层结构的依赖性逐渐增加有关。这个过程通常被称为系统整合理论。在本文中，我们首先回顾了如何记忆成为海马依赖的皮层依赖的HPC和皮层之间发生的相互作用，在系统巩固的重点。我们还回顾了HPC依赖性逐渐衰退的机制，在系统巩固的角度记忆擦除成人海马神经发生。最后讨论了系统合并与记忆精度的关系。
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision.