Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae
Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae
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DOI：
10.1128/aac.02069-17
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发表时间：
2018-03-01
影响因子：
4.9
通讯作者：
Ohnishi, Makoto
中科院分区：
文献类型：
--
作者：
Igawa, Gene;Yamagishi, Yuka;Ohnishi, Makoto
花叶 penA 等位基因引起了淋病奈瑟菌的大部分头孢菌素耐药性，但其进化大多未知。来自灰奈瑟菌AM1601菌株的penA基因（头孢曲松MIC，1.0μg/ml）在头孢曲松敏感的淋球菌菌株中引起头孢曲松耐药性（MIC，1μg/ml）。 AM1601 penA 的 3' 末端一半与头孢曲松耐药淋球菌 GU140106 和 FC428 菌株的 3' 末端几乎相同。灰霉病菌可以作为介导头孢曲松耐药性的 penA 序列的储存库，这些序列可以转移到淋球菌中。
Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae, but their evolution is mostly unknown. The penA gene from Neisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 mu g/ml) caused ceftriaxone resistance (MIC, 1 mu g/ml) in a ceftriaxone-susceptible gonococcal strain. The 3'-terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that can be transferred to gonococci.