Effect of Exericse and Nutrition upon Lifestyle-Related Disease and Cognitive Function
Effect of Exericse and Nutrition upon Lifestyle-Related Disease and Cognitive Function
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DOI：
10.3177/jnsv.61.s122
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发表时间：
2015-05-01
影响因子：
1.6
通讯作者：
Akamatsu, Yasunori
中科院分区：
文献类型：
--
作者：
Moritani, Toshio;Akamatsu, Yasunori
布雷提出了“蒙娜丽莎”假说，即大多数已知肥胖都是交感神经活动低的首字母缩略词，表明肥胖与交感神经系统产热成分活动的相对或绝对减少有关。我们的一系列研究表明，ANS活动调节脂肪代谢和食欲控制的潜在可逆性，可以通过定期运动训练来调节中年个体和肥胖儿童的ANS活动。换句话说，习惯性运动不仅在促进脂肪和葡萄糖代谢方面发挥重要作用，而且在预防肥胖和控制食欲方面也发挥着重要作用。越来越多的人认为，久坐对健康是一种真实而重大的风险。这些加速度计测量研究的一个有趣发现是，久坐时间的休息被证明与代谢生物标志物有有益的联系，这可能是由于挑战和增强了调节体重和食欲的自主神经系统。脑源性神经营养因子（BDNF）的最新发现似乎揭示了一些与年龄相关的神经退行性疾病，并似乎影响能量代谢，食欲和神经认知功能的各个方面。这些数据有力地表明，以久坐不动的生活方式和不健康的饮食为特征的缺乏锻炼可能会导致加速衰老、身体和大脑疾病，以及生活质量的总体下降。
Bray has proposed the "MONA LISA" hypothesis, an acronym for Most Obesities kNown Are Low In Sympathetic Activity indicating that obesity is associated with a relative or absolute reduction in the activity of the thermogenic component of the sympathetic nervous system. Our series of studies have suggested a potential reversibility in ANS activity regulating fat metabolism and appetite control by regular exercise training in middle aged individuals and obese children with depressed ANS activity. In other words habitual exercise plays a vital role in enhancing not only fat and glucose metabolism, but also ANS activities in the prevention of obesity and appetite control. There are growing expectations that too much sitting is a real and substantial risk to health. One of the intriguing findings from these accelerometer measurement studies is that breaks in sedentary time were shown to have beneficial associations with metabolic biomarkers, due possibly to challenging and enhancing autonomic nervous system that regulates body weight and appetite. Recent findings of brain-derived neurotrophic factors (BDNF) seem to have shed some light upon age-related neurodegenerative diseases and appear to influence energy metabolism, appetite and aspects of neuro-cognitive function. These data strongly suggest that a lack of exercise as characterized by a sedentary lifestyle and an unhealthy diet may lead to accelerated ageing, diseases of the body and brain, and an overall decline in the quality of life.