ALTERED CORTICOSPINAL PROJECTIONS TO LOWER-LIMB MOTONEURONS IN SUBJECTS WITH CEREBRAL-PALSY
ALTERED CORTICOSPINAL PROJECTIONS TO LOWER-LIMB MOTONEURONS IN SUBJECTS WITH CEREBRAL-PALSY
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DOI：
10.1093/brain/114.3.1395
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发表时间：
1991-06-01
期刊：
影响因子：
14.5
通讯作者：
ASHBY, P
中科院分区：
文献类型：
--
作者：
BROUWER, B;ASHBY, P
本文观察了22例正常人和14例脑瘫患者经颅磁刺激激活的皮层神经元向下肢肌运动神经元的投射。 在正常受试者中，磁刺激产生强烈的胫骨前肌（TA）运动神经元的易化，但很少或没有促进比目鱼肌（SOL）运动神经元。 这种差异促进TA和SOL运动神经元观察到在头皮上的所有刺激部位和所有刺激强度，在该反应可以引起。 在主题与CP，磁刺激产生几乎相同的促进TA和SOL运动神经元。 这不能解释各自的运动神经元池的兴奋性的差异。 据推测，从运动皮层到脊髓运动神经元的投射在CP中被改变。 这些异常投射可能导致这些受试者所经历的自主运动受损。
The projections of cortical neurons activated by transcranial magnetic stimulation to the motoneurons of lower limb muscles were examined in 22 normal subjects and 14 subjects with cerebral palsy (CP). In normal subjects, magnetic stimulation produced strong facilitation of tibialis anterior (TA) motoneurons, but little or no facilitation of soleus (SOL) motoneurons. This differential facilitation of TA and SOL motoneurons was observed at all stimulus sites on the scalp and all stimulus intensities at which responses could be elicited. In subjects with CP, magnetic stimulation produced almost equal facilitation of TA and SOL motoneurons. This could not be explained by differences in the excitability of the respective motoneuron pools. It is postulated that the projections from the motor cortex to spinal motoneurons are altered in CP. These abnormal projections may contribute to the impairment of voluntary movements experienced by these subjects.