Caffeine inhibits development of benign mammary gland tumors in carcinogen-treated female Sprague-Dawley rats.
Caffeine inhibits development of benign mammary gland tumors in carcinogen-treated female Sprague-Dawley rats.
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咖啡因抑制经致癌物治疗的雌性斯普拉格-道利大鼠良性乳腺肿瘤的发展。
DOI：
10.1007/bf01961163
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发表时间：
1991
影响因子：
3.8
通讯作者：
Welsch,CW
中科院分区：
文献类型：
--
作者：
Wolfrom,DM;Rao,AR;Welsch,CW
本研究的目的是评估咖啡因对致癌物（DMBA）处理的雌性Sprague-Dawley大鼠良性乳腺肿瘤发病率的影响。在这些研究中使用了四种不同的动物模型，即，DMBA的管理：[1] 55日龄未交配大鼠; [2] 53日龄卵巢切除、雌激素处理的未交配大鼠; [3] 135日龄未交配大鼠和[4] 135日龄经产大鼠。在四种动物模型中均观察到良性乳腺纤维腺瘤的高发病率。此外，在雌激素处理的卵巢切除动物中，观察到分泌性乳腺囊肿的高发病率。在致癌物处理后3-31天开始的整个研究期间，每天给予咖啡因（500 mg/L饮用水）。咖啡因治疗显著（P<0.05至P<0.001）降低了55日龄处女大鼠模型（P<0.01）、53日龄雌激素治疗的卵巢切除处女大鼠模型（P<0.05至P<0.001）和135日龄处女大鼠模型（P<0.05）中良性乳腺纤维腺瘤的发病率。在135日龄经产大鼠模型中，咖啡因可减少良性乳腺纤维腺瘤的数量，但这种减少并不显着（P<0.10）。此外，在雌激素治疗的去势雌性大鼠模型中，咖啡因可显著降低乳腺囊肿的发生率（P<0.05 ~ P<0.001）。根据动物模型，咖啡因治疗增加或对体重增加无显著影响。因此，咖啡因摄入量可影响致癌物处理的雌性Sprague-Dawley大鼠中良性乳腺肿瘤（纤维腺瘤和囊肿）的发展，这种影响显示出持续的抑制作用。
The purpose of this study was to assess the influence of caffeine on the incidence of benign mammary tumors in carcinogen (DMBA) treated female Sprague-Dawley rats. Four different animal models were used in these studies, i.e., the administration of DMBA to: [1] 55 day old virgin rats; [2] 53 day old ovariectomized, estrogen treated virgin rats; [3] 135 day old virgin rats and [4] 135 day old parous rats. A high incidence of benign mammary fibroadenomas was observed in each of the four animal models. In addition, in the estrogen treated ovariectomized animals, a high incidence of secretory mammary gland cysts was observed. Caffeine (500 mg/L drinking water) was administered daily throughout the study commencing 3–31 days after carcinogen treatment. Caffeine treatment significantly (P<0.05 to P<0.001) reduced the incidence of benign mammary fibroadenomas in the 55 day old virgin rat model (P<0.01), in the 53 day old estrogen treated ovariectomized virgin rat model (P<0.05 to P<0.001) and in the 135 day old virgin rat model (P<0.05). The number of benign mammary fibroadenomas was reduced by caffeine in the 135 day old parous rat model but this reduction was not significant (P<0.10). In addition, in the estrogen treated ovariectomized virgin rat model, caffeine significantly (P<0.05 to P<0.001) reduced the incidence of mammary gland cysts. Caffeine treatment either increased or had no significant effect on body weight gains, depending upon the animal model. Thus, caffeine consumption can influence the development of benign mammary tumors (fibroadenomas and cysts) in carcinogen treated female Sprague-Dawley rats, an influence that was shown to be consistently inhibitory.