Plant metabolic clusters - from genetics to genomics.
Plant metabolic clusters - from genetics to genomics.
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DOI：
10.1111/nph.13981
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Osbourn A
中科院分区：
文献类型：
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作者：
Nützmann HW;Huang A;Osbourn A
植物天然产物在农业、医药和其他广泛的工业应用中具有重要价值。新的植物天然产物途径的发现目前正受到两个关键发展的革命性影响。首先，测序技术的突破和测序成本的降低正在通过识别潜在基因加速发现新的天然产物生物合成的酶和途径的能力。其次，现在有多个例子表明，在植物基因组中，编码某些天然产物途径的基因被归类为生物合成基因簇。这些进步使我们有可能制定策略，系统地挖掘多种植物基因组，以发现新的酶、途径和化学物质。增加对植物代谢基因簇特征的了解-结构，调节和组装-将有助于加快天然产物的发现。本文综述了这一领域的进展。
Plant natural products are of great value for agriculture, medicine and a wide range of other industrial applications. The discovery of new plant natural product pathways is currently being revolutionized by two key developments. First, breakthroughs in sequencing technology and reduced cost of sequencing are accelerating the ability to find enzymes and pathways for the biosynthesis of new natural products by identifying the underlying genes. Second, there are now multiple examples in which the genes encoding certain natural product pathways have been found to be grouped together in biosynthetic gene clusters within plant genomes. These advances are now making it possible to develop strategies for systematically mining multiple plant genomes for the discovery of new enzymes, pathways and chemistries. Increased knowledge of the features of plant metabolic gene clusters – architecture, regulation and assembly – will be instrumental in expediting natural product discovery. This review summarizes progress in this area.