A head mounted device stimulator for optogenetic retinal prosthesis.
A head mounted device stimulator for optogenetic retinal prosthesis.
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DOI：
10.1088/1741-2552/aadd55
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发表时间：
2018-12
影响因子：
4
通讯作者：
Degenaar P
中科院分区：
文献类型：
--
作者：
Soltan A;Barrett JM;Maaskant P;Armstrong N;Al-Atabany W;Chaudet L;Neil M;Sernagor E;Degenaar P
Objective.我们的主要目标是证明，紧凑的高辐射氮化镓显示器可以与传统的虚拟现实光学刺激光遗传视网膜。因此，我们的目标是引入一种非侵入性的方法来恢复患有视网膜色素变性等疾病的人的视力，在这些疾病中，视网膜和视觉皮层之间仍然存在可行的通信联系。Approach.我们使用高密度µLED矩阵、Raspberry Pi、恩智浦微控制器和虚拟现实透镜设计并实现了该耳机。然后，开发了一个测试平台，以评估耳机和光学系统的性能。此外，图像简化算法用于简化要发送到视网膜的场景。此外，在不同的光强度下的转基因视网膜反应的体内评价进行了讨论，以证明所提出的系统的可靠性。主要结果。我们证明，为了符合监管指南，耳机显示器需要将其亮度限制在90 kcd m−2。我们展示了一个光学系统，其效率为5.75%，在规定的指导范围内，视网膜上的辐照度为0.16 mW mm-2，但平均峰值辐照度为1.35 mW mm-2。由于这低于通道视紫红质-2的普遍接受的阈值，我们通过眼睛的光学模型在生物视网膜上证明了功效。意义我们展示了一个功能齐全的8100像素耳机系统，包括软件/硬件，可以运行在一个标准的消费电池超过24小时的充电周期。该耳机能够提供足够的光线来刺激转基因视网膜细胞，并将光量保持在安全的调节阈值以下。
Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. Approach. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. Main results. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m−2. We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm−2 irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm−2. As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Significance. We demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24 h recharge cycle. The headset is capable of delivering enough light to stimulate the genetically modified retina cells and also keeping the amount of light below the regulation threshold for safety.
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影响因子：
2.4
作者：
Hu, Jie;Xia, Peng;Peng, Yinghong
通讯作者：
Peng, Yinghong
影响因子：
5.3
作者：
Barrett JM;Degenaar P;Sernagor E
通讯作者：
Sernagor E
影响因子：
3.7
作者：
Bergs A;Schultheis C;Fischer E;Tsunoda SP;Erbguth K;Husson SJ;Govorunova E;Spudich JL;Nagel G;Gottschalk A;Liewald JF
通讯作者：
Liewald JF
影响因子：
11.1
作者：
Cronin T;Vandenberghe LH;Hantz P;Juttner J;Reimann A;Kacsó AE;Huckfeldt RM;Busskamp V;Kohler H;Lagali PS;Roska B;Bennett J
通讯作者：
Bennett J
影响因子：
4.4
作者：
Aleman, TS;Jacobson, SG;Cideciyan, AV
通讯作者：
Cideciyan, AV