Enzymology of the hair follicle.
Enzymology of the hair follicle.
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毛囊的酶学。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
R. Hoffmann
中科院分区：
文献类型：
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作者：
R. Hoffmann
雄激素性脱发（AGA）是男性和女性中最常见的脱发类型。这种持续的过程导致了一种脱发，这种脱发在遗传易感性的个体中遵循一定的模式。遗传易感性是AGA的一个特征，但易感性基因仍然未知。然而，我们对激素对头发生长的影响的了解还远远不够，人类毛囊不仅是雄激素的目标，而且还显示出活跃的雄激素代谢，具有通过不同的类固醇酶转化几种雄激素的能力。最近的研究结果表明，毛囊真皮乳头表达丰富的2 - 5a-还原酶、3b-HSD和类固醇硫酸酯酶活性。因此，本文综述了目前有关毛囊雄激素代谢的信息，并讨论了对未来治疗方法的潜在影响。
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. This continuous process results in a type of alopecia that follows a definite pattern in those individuals who are genetically predisposed. A genetic predisposition is a feature of AGA, but the predisposing genes are still unknown. Our understanding, however, of the hormonal effects on hair growth is far move advanced, and human hair follicles are not only targets for androgens, but also reveal an active androgen metabolism, with the ability to convert several androgens by different steroidogenic enzymes. Recent results suggest that the dermal papilla of the hair follicle expresses abundant type 2 5a-reductase, 3b-HSD and steroid sulfatase activity. Therefore, current information about the androgen metabolism in hair follicles is reviewed and the potential impact on future therapeutic approaches is discussed.