Release and vasoconstrictor effect of leukotriene C-like immunoreactive material in the anaphylactic guinea-pig mesenteric vascular bed.
Release and vasoconstrictor effect of leukotriene C-like immunoreactive material in the anaphylactic guinea-pig mesenteric vascular bed.
复制标题
过敏性豚鼠肠系膜血管床中白三烯 C 样免疫反应物质的释放和血管收缩作用。
DOI：
10.1016/0014-2999(84)90166-3
复制
发表时间：
1984
影响因子：
5
通讯作者：
B. Peskar
中科院分区：
文献类型：
--
作者：
A. Dembińska;T. Simmet;B. Peskar
在恒压下灌注的致敏离体豚鼠肠系膜的抗原攻击导致流量显着减少，同时白三烯 (LT)C4 样免疫反应性释放到灌注液中。脂氧合酶抑制剂槲皮素抑制免疫反应性LTC4的释放，同时消除抗原诱导的肠系膜流量减少。注射外源性LTC4后还观察到肠系膜流量减少。结果表明，LTC4 是肠系膜血管床的收缩剂，并且内源性 LTC4 样免疫反应物质是豚鼠肠系膜中过敏性血管收缩的介质。
Antigen challenge of sensitized isolated guinea-pig mesentery perfused under constant pressure resulted in a significant flow reduction, which was paralleled by the release of leukotriene (LT)C4-like immunoreactivity into the perfusates. The lipoxygenase inhibitor quercetin inhibited the release of immunoreactive LTC4and simultaneously abolished the antigen-induced mesenteric flow reduction. Mesenteric flow reduction was also observed after injection of exogenous LTC4. The results demonstrate that LTC4is a constrictor of the mesenteric vascular bed and that endogenous LTC4-like immunoreactive material is a mediator of anaphylactic vasoconstriction in the guinea-pig mesentery.
DOI：
10.1073/pnas.77.7.4354
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DRAZEN, JM;AUSTEN, KF;COREY, EJ
通讯作者：
COREY, EJ