Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams
Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams
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DOI：
10.1055/s-0036-1588672
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发表时间：
2017-04-01
影响因子：
2.6
通讯作者：
Orru, Romano V. A.
中科院分区：
文献类型：
--
作者：
Cioc, Razvan C.;van Riempst, Lola Schaepkens;Orru, Romano V. A.
本文报道了用Ugi四中心三组分反应（U4C-3CR）合成小分子药物消旋胺的方法。在Ugi反应中首次采用-氨基丁酸作为双功能输入。该方案简单，通用，并允许一锅访问一系列药物和生物活性小分子。
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, gamma-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol is simple, general, and allows one-pot access to a range of drugs and bioactive small mole-cules.