Prevalence and risk factors of musculoskeletal pain symptoms as long-term post-COVID sequelae in hospitalized COVID-19 survivors: a multicenter study
Prevalence and risk factors of musculoskeletal pain symptoms as long-term post-COVID sequelae in hospitalized COVID-19 survivors: a multicenter study
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DOI：
10.1097/j.pain.0000000000002564
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发表时间：
2022-09-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, Lars
中科院分区：
文献类型：
--
作者：
Fernandez-de-las-Penas, Cesar;De-la-Llave-Rincon, Ana, I;Arendt-Nielsen, Lars
本研究调查了大量COVID-19幸存者中COVID-19后长期肌肉骨骼疼痛的患病率及其危险因素。开展了一项多中心队列研究，包括在大流行第一波期间在马德里（西班牙）5家医院因COVID-19住院的患者。从医疗记录中收集住院和临床数据。出院后对患者进行电话访谈，收集有关covid后肌肉骨骼疼痛的数据。焦虑/抑郁水平和睡眠质量也同样被评估。从招募的2000名患者中，共有1969名患者（46.4%为女性，年龄：61岁，SD: 16岁）在出院后8.4个月（SD: 1.5个月）平均接受评估。在研究期间，887人（45%的女性）报告了covid后肌肉骨骼疼痛。根据既往疼痛症状的存在，“新发”（新发）肌肉骨骼在covid后疼痛的患病率为74.9%，而25.1%的患者既往症状加重（与covid相关的疼痛加重）。女性（优势比[OR]: 1.349, 95%可信区间[CI]: 1.059-1.720）、肌肉骨骼疼痛史（OR 1.553, 95% CI 1.272 -1.898）、肌痛（OR 1.546, 95% CI 1.155-2.070）和头痛（OR 1.866, 95% CI 1.349-2.580）作为与covid -19相关的发病症状，以及住院天数（OR 1.013, 95% CI 1.004-1.022）是与covid -19后肌肉骨骼疼痛相关的危险因素。总之，45.1%的COVID-19幸存者在出院后8个月出现肌肉骨骼疼痛，大多数患者出现新冠后疼痛。女性、肌肉骨骼疼痛史、急性期出现肌痛和头痛症状以及住院天数是与COVID-19后肌肉骨骼疼痛相关的危险因素。
This study investigated the prevalence of long-term musculoskeletal post-COVID pain and their risk factors in a large cohort of COVID-19 survivors. A multicenter cohort study including patients hospitalised because of COVID-19 in 5 hospitals of Madrid (Spain) during the first wave of the pandemic was conducted. Hospitalisation and clinical data were collected from medical records. Patients were scheduled for a telephone interview after hospital discharge for collecting data about the musculoskeletal post-COVID pain. Anxiety/depressive levels and sleep quality were likewise assessed. From 2000 patients recruited, a total of 1969 individuals (46.4% women, age: 61 years, SD: 16 years) were assessed on average at 8.4 (SD: 1.5) months after discharge. At the time of the study, 887 (45% women) reported musculoskeletal post-COVID pain. According to the presence of previous pain symptoms, the prevalence of "de novo" (new-onset) musculoskeletal post-COVID pain was 74.9%, whereas 25.1% experienced an increase in previous symptoms (exacerbated COVID-related pain). Female sex (odds ratio [OR]: 1.349, 95% confidence interval [CI]: 1.059-1.720), history of musculoskeletal pain (OR 1.553, 95% CI 1.271-1.898), presence of myalgia (OR 1.546, 95% CI 1.155-2.070) and headache (1.866, 95% CI 1.349-2.580) as COVID-19-associated onset symptoms, and days at hospital (OR 1.013, 95% CI 1.004-1.022) were risk factors associated with musculoskeletal post-COVID pain. In conclusion, musculoskeletal post-COVID pain is present in 45.1% of COVID-19 survivors at 8 months after hospital discharge with most patients developing de novo post-COVID pain. Female sex, history of musculoskeletal pain, presence of myalgia and headache as COVID-19 symptoms at the acute phase, and days at hospital were risk factors associated with musculoskeletal post-COVID pain.