Histone demethylase lysine demethylase 5B in development and cancer.
Histone demethylase lysine demethylase 5B in development and cancer.
复制标题
组蛋白去甲基化酶赖氨酸去甲基化酶 5B 在发育和癌症中的作用
DOI：
10.18632/oncotarget.13858
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发表时间：
2017-01-31
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Han M;Xu W;Cheng P;Jin H;Wang X
组蛋白甲基化是最重要的染色质翻译后修饰之一。它对核功能有一系列影响，包括表观遗传、转录调控和基因组完整性的维持。组蛋白甲基化状态的改变参与了多种生理和病理过程。KDM 5 B（lysine demethylase 5 B，也称为JARID 1B或PLU-1）编码组蛋白H3 lysine 4（H3 K4）去甲基化酶，并且表现出强的转录抑制活性。KDM 5 B在细胞分化、干细胞自我更新和其他发育过程中发挥作用。近年来的研究表明，KDM 5 B在乳腺、膀胱、肺、前列腺等多种肿瘤中表达增加，促进肿瘤的发生、侵袭和转移。鉴于其与肿瘤进展和癌症患者预后的相关性，KDM 5 B被认为是预防和治疗人类癌症的新靶点。在这篇综述中，我们将总结最近的进展，我们了解的调控和功能的KDM 5 B的发展和癌症。
Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes. KDM5B (lysine demethylase 5B, also called JARID1B or PLU-1) encodes the histone H3 lysine4 (H3K4) demethylase and exhibits a strong transcriptional repression activity. KDM5B plays a role in cell differentiation, stem cell self-renewal and other developmental progresses. Recent studies showed that KDM5B expression was increased in breast, bladder, lung, prostate and many other tumors and promotes tumor initiation, invasion and metastasis. Given its association with tumor progression and prognosis of cancer patients, KDM5B was proposed to be a novel target for the prevention and treatment of human cancers. In this review, we will summarize recent advances in our understanding of the regulation and function of KDM5B in development and cancer.