Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins
Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins
复制标题
希氏扁豆乳杆菌 H-50 通过其特定的表面层蛋白强烈抑制脂多糖诱导的小鼠脾细胞炎症反应
DOI：
10.1093/jambio/lxad021
复制
发表时间：
2023
影响因子：
4
通讯作者：
Yamamoto Yoshinari
中科院分区：
文献类型：
--
作者：
Yamaguchi Tomofumi;Yasui Kenta;Fujii Sotaro;Ichikawa Kennosuke;Suzuki Takuya;Sambongi Yoshihiro;Yamamoto Yoshinari
目的已知某些乳酸菌（LAB）具有抗炎作用;然而，在分类学上被归类为LAB并已知破坏传统日本酒精饮料的hiochi细菌尚未在相同的背景下进行研究。本研究的目的是探讨hiochi细菌菌株的抗炎作用和潜在的mechanism.Methods和ResultsWe筛选了45株hiochi细菌的抗炎作用，发现LentilichilgardiiH-50强烈抑制脂多糖（LPS）诱导的小鼠脾细胞分泌肿瘤坏死因子（TNF）-α，白细胞介素（IL）-1β和IL-6。这种抑制作用是由于其特异性的表面层蛋白（SLP）直接与LPS结合所致。hilgardii H-50菌株通过其SLP发挥抗炎作用。
AimsCertain lactic acid bacteria (LAB) are known to have anti-inflammatory effects; however, hiochi bacteria, which are taxonomically classified as LAB and known to spoil a traditional Japanese alcoholic beverage, have not been studied in the same context. The aim of this study is to investigate the anti-inflammatory effects of hiochi bacteria strains and the underlying mechanisms.Methods and ResultsWe screened 45 strains of hiochi bacteria for anti-inflammatory effects and found thatLentilactobacillus hilgardiiH-50 strongly inhibits lipopolysaccharide (LPS)-induced secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mouse splenocytes. This inhibition is attributed to its specific surface layer proteins (SLPs), which directly bind to LPS.ConclusionsTheL. hilgardiiH-50 strain exerts anti-inflammatory effects through its SLPs.