Hyperuricemia and its related factors in an urban population, Izmir, Turkey
Hyperuricemia and its related factors in an urban population, Izmir, Turkey
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DOI：
10.1007/s00296-008-0806-2
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发表时间：
2009-06-01
影响因子：
4
通讯作者：
Akkoc, Nurullah
中科院分区：
文献类型：
--
作者：
Sari, Ismail;Akar, Servet;Akkoc, Nurullah
本研究的目的是探讨高尿酸血症的患病率及其相关因素在城市地区的伊兹密尔，位于土耳其西部。我们的研究组是通过计算机抽样从一项更大的基于人群的研究的参与者中选出的，该研究旨在寻找伊兹密尔的Balcova和Narlidere地区类风湿性关节炎的患病率。本研究共纳入132例受试者（69例女性和63例男性）。血清尿酸，血糖，肌酐和血脂水平进行了研究。身体组成沿着与体脂百分比测定人体测量。共有16例受试者患有高尿酸血症（4例女性和12例男性）。高尿酸血症的总体患病率为12.1%，平均尿酸水平为4.9 +/- A 1.3 mg/dl。男性的尿酸水平显著高于女性（P < 0.05;分别为5.5 +/- A 1.3和4.3 +/- A 1.1 mg/dl）。高血压、糖尿病、肥胖和代谢综合征的患病率分别为24.4%、5.3%、28%和26.5%。无痛风受试者。皮褶厚度（SFT）测量值和肌酐水平的总和是高尿酸血症的独立预测因子（β = 0.45，0.47，分别）。尿酸测定不仅对炎症性风湿性疾病很重要，而且对预测代谢综合征和相关冠状动脉疾病也很重要。尿酸水平存在性别差异，女性最可能的原因是性腺激素。人体测量SFT是一种简单的临床筛查方法，与肌酐水平一起沿着，可显著预测高尿酸血症。
The aim of this study was to examine the prevalence of hyperuricemia and its associated factors in an urban area of Izmir, located in western Turkey. Our study group was selected by computerized sampling from the participants of a larger population-based study searching for the prevalence of rheumatoid arthritis in Balcova and Narlidere districts of Izmir. A total of 132 subjects (69 women and 63 men) were included in this study. Serum uric acid, glucose, creatinine and lipid levels were studied. Body composition along with body fat percentage was determined anthropometrically. A total of 16 subjects had hyperuricemia (4 women and 12 men). The overall prevalence of hyperuricemia was 12.1% and the mean uric acid level was 4.9 +/- A 1.3 mg/dl. Males had significantly higher uric acid levels than females (P < 0.05; 5.5 +/- A 1.3 vs. 4.3 +/- A 1.1 mg/dl, respectively). The prevalence of hypertension, diabetes, obesity and metabolic syndrome was 24.4, 5.3, 28 and 26.5%, respectively. There was no gouty subject. Sum of skinfold thickness (SFT) measurements and creatinine levels were the independent predictors of hyperuricemia (beta = 0.45, 0.47, respectively). Uric acid measurement is important not only for inflammatory rheumatic disorders but also for predicting metabolic syndrome and related coronary artery disease. There is sex difference in uric acid levels in favor of women most probably explained by gonadal hormones. Hyperuricemia is significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine levels.