NITRITE THIOSULFATE TREATED ACUTE CYANIDE POISONING - ESTIMATED KINETICS AFTER ANTIDOTE
NITRITE THIOSULFATE TREATED ACUTE CYANIDE POISONING - ESTIMATED KINETICS AFTER ANTIDOTE
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DOI：
10.3109/15563658708992618
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
RUMACK, BH
中科院分区：
文献类型：
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作者：
HALL, AH;DOUTRE, WH;RUMACK, BH
一名34岁，73公斤的男子在自杀企图中摄入了1克氰化钾丸。一小时内，出现昏迷、呼吸暂停、代谢性酸中毒和癫痫发作。给予硝酸钠和硫代硫酸钠。完成解毒剂输注后，临床情况有显著改善。给亚硝酸盐后高铁血红蛋白水平为2%。获得了一系列全血氰化物水平，记录最高测量水平为15.68微克/毫升。计算了毒理动力学参数的估计，包括末端半衰期（t 1/2）（19小时）、清除率（163 mL/min）和分布体积（Vd） （0.41 L/kg）。亚硝酸盐/硫代硫酸盐联合治疗临床有效，患者完全康复。
A 34 year old, 73 kg man ingested a 1 gram potassium cyanide pellet in a suicide attempt. Within one hour, coma, apnea, metabolic acidosis, and seizures developed. Sodium nitrate and sodium thiosulfate were administered. Dramatic improvement in the clinical condition occurred by the completion of antidote infusion. Methemoglobin level was 2% immediately after nitrite administration. Serial whole blood cyanide levels were obtained, documenting a highest measured level of 15.68 mcg/mL. Estimations of toxicokinetic parameters including terminal half-life (t 1/2) (19 hours), clearance (163 mL/minute), and volume of distribution (Vd) (0.41 L/kg) were calculated. The nitrite/thiosulfate combination was clinically efficacious in this case and resulted in complete recovery.