The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae
The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae
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DOI：
10.1016/s0264-410x(00)00285-1
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发表时间：
2000-12-08
期刊：
影响因子：
5.5
通讯作者：
Brooks-Walter, A
中科院分区：
文献类型：
--
作者：
Briles, DE;Hollingshead, SK;Brooks-Walter, A
针对中耳炎的潜在疫苗策略是预防（I）中耳症状感染和/或（2）肺炎球菌携带以及随后的中耳感染。已经检查了利用对肺炎球菌毒力蛋白的免疫力来引发针对肺炎球菌的免疫力的可能性。 PspA 已被发现对动物中耳炎有效。据观察，与单独接种任一蛋白质相比，使用 PsaA 和 PspA 混合物进行疫苗接种可以更好地防止小鼠鼻携带。 PspA 和肺炎球菌溶血素已被证明可以针对侵袭性感染提供保护。将这些蛋白质中的一些包含到多糖-蛋白质缀合物疫苗中可能能够增强其针对中耳炎的功效，并且可能能够构成成功的全蛋白质肺炎球菌疫苗。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Potential vaccine strategies against otitis media are to prevent (I) symptomatic infections in the middle ear and/or (2) carriage of pneumococci and thereby subsequent middle ear infections. The possibility of using immunity to virulence proteins of pneumococci to elicit immunity against pneumococci has been examined. PspA, has been found to have efficacy against otitis media in animals. Vaccination with a mixture of PsaA and PspA has been observed to offer better protection against nasal carriage in mice, than vaccination with either protein alone. PspA and pneumolysin have been shown to elicit protection against invasive infections. The inclusion of a few of these proteins into the polysaccharide-protein conjugate vaccines may be able to enhance their efficacy against otitis media and might be able to constitute a successful all-protein pneumococcal vaccine. (C) 2000 Elsevier Science Ltd. All rights reserved.