The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium
The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium
复制标题
DOI：
10.1016/j.biomaterials.2009.11.114
复制
发表时间：
2010-03-01
期刊：
影响因子：
14
通讯作者：
Jansen, John A.
中科院分区：
文献类型：
--
作者：
de Jonge, Lise T.;Leeuwenburgh, Sander C. G.;Jansen, John A.
用于骨科和牙科植入物。最终目标是使种植体在原生周围骨骼中获得终生安全锚定。为此，使用电喷雾沉积 (ESD) 技术成功沉积了纳米级磷酸钙 (CaP) 和胶原蛋白-CaP (col-Call) 复合涂层。为了研究这些涂层的厚度可以减少到什么程度而不损失涂层的成骨特性，我们使用胶带测试（ASTM D-3359）和体外细胞培养实验来表征涂层的机械和生物特性。胶原蛋白的共沉积分别显着提高了涂层的粘合力和内聚强度。体外细胞培养实验表明，电喷雾 CaP 和 col-CaP 复合涂层增强了成骨细胞分化，从而改善了矿物质沉积，这种效果在胶原蛋白与 CaP 共沉积时最为明显。即使涂层厚度低于 100 nm，这些涂层也显示出成骨作用 (C) 2009 Elsevier Ltd 保留所有权利
For orthopedic and dental Implants. the ultimate goal is to obtain a life-long Secure anchoring of the implant in the native surrounding bone To this end, nanoscale calcium phosphate (CaP) and collagen-CaP (col-Call) composite coatings have been successfully deposited using the electrospray deposition (ESD) technique. In order to study to what extent the thickness of these coatings can be reduced Without losing coating osteogenic properties, we have characterized the mechanical and biological coating properties using tape tests (ASTM D-3359) and in vitro cell culture experiments. respectively Co-deposition of collagen significantly Improved coating adhesive and cohesive strength. resulting In a remarkably high coating retention Of up to 97% for coating thicknesses below 100 rim in vitro cell Culture experiments showed that electrosprayed CaP and col-CaP composite coatings enhanced osteoblast differentiation, leading to Improved mineral deposition This effect was most pronounced upon Co-deposition of collagen with CaP. and these coatings displayed osteogenic effects even for a coating thickness of below 100 nm (C) 2009 Elsevier Ltd All rights reserved