Glutamate agonist activity: Implications for antipsychotic drug action and schizophrenia
Glutamate agonist activity: Implications for antipsychotic drug action and schizophrenia
复制标题
DOI：
10.1097/00001756-199512150-00014
复制
发表时间：
1995-12-15
期刊：
影响因子：
1.7
通讯作者：
Lidsky, TI
中科院分区：
文献类型：
--
作者：
Banerjee, SP;Zuck, LG;Lidsky, TI
多巴胺D2受体的拮抗剂作用似乎可以解释抗精神病药物的许多作用，但不是所有作用。由于多巴胺与谷氨酸的相互作用，以及后者在精神分裂症病因学中的意义，在本实验中评估了抗精神病药物对谷氨酸受体的可能影响。这些研究表明，在临床相关浓度下，常规抗精神病药物氟哌啶醇和非典型抗精神病药物氯氮平对NMDA受体具有强效增强作用。这些数据表明，谷氨酸受体的独特作用可能有助于抗精神病药的疗效，并强调了谷氨酸能功能障碍在精神分裂症病因学中的潜在重要性。
ANTAGONIST action at dopamine D2 receptors appears to explain many, but not all of the effects of antipsychotic drugs. Because of the interactions of dopamine with glutamate, and the implication of the latter in the etiology of schizophrenia, possible effects of antipsychotic drugs on glutamate receptors were assessed in the present experiments. These studies showed that, at clinically relevant concentrations, the conventional neuroleptic haloperidol and the atypical antipsychotic clozapine had potent augmenting influences on the NMDA receptor. These data suggest that unique action at glutamate receptors may contribute to antipsychotic efficacy and emphasize the potential importance of glutamatergic dysfunction in the etiology of schizophrenia.