The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer
The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer
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DOI：
10.1093/carcin/21.7.1281
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发表时间：
2000-07-01
期刊：
影响因子：
4.7
通讯作者：
Perera, FP
中科院分区：
文献类型：
--
作者：
Rundle, A;Tang, DL;Perera, FP
许多多环芳烃(PAH)是一种广泛存在的环境污染物，实验上会导致乳腺癌。我们调查了乳腺组织中PAH-DNA加合物测量的PAH暴露和对PAH的敏感性是否与人类乳腺癌有关。我们开展了一项以医院为基础的病例对照研究，用免疫组织化学方法分析了肿瘤和非肿瘤乳腺组织中的PAH-DNA加合物，以及来自病例和对照的良性乳腺组织。受试者为白人、非裔美国人和拉丁裔妇女，包括119名乳腺癌患者和108名无异型性的良性乳腺疾病患者。在控制了已知的乳腺癌危险因素、当前主动吸烟和被动吸烟以及饮食中的多环芳烃后，100例患者的乳腺肿瘤组织和105名对照组正常组织中的泛DNA加合物与乳腺癌显著相关(OR=4.43，96%可信区间1.09-18.01)。在控制了潜在的混杂因素后，肿瘤组织中加合物升高与对照组织相比的优势比为2.56(1.05-6.24)。肿瘤组织中的加合物水平不随分期或肿瘤大小而变化。在86例配对的肿瘤组织和非肿瘤组织中，两者的加合物水平高度相关(r=0.56，P
A number of polycyclic aromatic hydrocarbons (PAH) are widespread environmental contaminants that cause mammary cancer experimentally. We investigated whether exposure and susceptibility to PAH, as measured by PAH-DNA adducts in breast tissue, are associated with human breast cancer. We carried out a hospital-based case-control study using immunohistochemical methods to analyze PAH-DNA adducts in tumor and nontumor breast tissue from cases and benign breast tissue from controls. The subjects were white, African-American and Latina women without prior cancer or treatment, including 119 women with breast cancer and 108 with benign breast disease without atypia, PAN-DNA adducts measured in breast tumor tissue of 100 cases and in normal tissue from 105 controls were significantly associated with breast cancer (OR = 4.43, 96% CI 1.09-18.01) after controlling for known breast cancer risk factors and current active and passive smoking, and dietary PAH, There was substantial interindividual (17-fold) variability in adducts overall, with 27% of cases and 13% of controls having elevated adducts, The odds ratio for elevated adducts in tumor tissue compared with control tissue was 2.56 (1.05-6.24), after controlling for potential confounders. Adduct levels in tumor tissue did not vary by stage or tumor size. Among 86 cases with paired tumor and nontumor tissue, adducts levels in these two tissues were highly correlated (r = 0.56, P