RETARDING EFFECT OF LOWERED HEART-RATE ON CORONARY ATHEROSCLEROSIS
RETARDING EFFECT OF LOWERED HEART-RATE ON CORONARY ATHEROSCLEROSIS
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DOI：
10.1126/science.6484569
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
ZARINS, CK
中科院分区：
文献类型：
--
作者：
BEERE, PA;GLAGOV, S;ZARINS, CK
在成年雄性食蟹猴（Macaca fascicularis）中评估了心率在冠状动脉粥样硬化发展中的作用。通过手术消融窦房结，6只动物的心率降低。在8只动物中进行假手术，包括除窦房结消融外的所有手术步骤。所有的猴子喂养致动脉粥样硬化的高胆固醇饮食6个月。在24小时的测试期间通过遥测技术重复监测心率。对于所有接受手术的动物来说，术后心率低于术前平均值的动物的冠状动脉粥样硬化不到心率高于平均值的动物或未接受手术的饮食对照动物的一半。各组在血压、血脂或体重方面没有差异。心率本身可能有助于行为模式和体育锻炼影响冠状动脉疾病的机制。
The role of heart rate in the development of coronary atherosclerosis was assessed in adult male cynomolgus monkeys (Macaca fascicularis). Heart rate was lowered in 6 animals by surgical ablation of the sinoatrial node. A sham procedure, which included all of the surgical steps except for sinoatrial node ablation, was carried out in 8 animals. All of the monkeys were fed an atherogenic high cholesterol diet for 6 mo. and heart rates were monitored repeatedly by telemetry during 24-h test periods. Coronary atherosclerosis in animals with postoperative heart rates less than the preoperative mean for all of the animals that underwent surgery was less than half that of animals with heart rates above the mean or of diet-fed control animals not subjected to surgery. Groups did not differ in blood pressure, serum lipids or body weight. Heart rate in itself may contribute to the mechanisms by which behavioral patterns and physical training influence coronary artery disease.