Selective cleavage of vancosamine, glucose, and N-methyl-leucine from vancomycin and related antibiotics
Selective cleavage of vancosamine, glucose, and N-methyl-leucine from vancomycin and related antibiotics
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DOI：
10.1039/c39880001306
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
R. Nagarajan;A. A. Schabel-A.
中科院分区：
文献类型：
--
作者：
R. Nagarajan;A. A. Schabel-A.
万古霉素及相关抗生素与三氟乙酸在-15℃下反应40 h，选择性裂解氨基糖万古胺；第二种糖葡萄糖与三氟乙酸在50°C下反应3 h， n端亮氨酸部分采用Edman降解法裂解。
Reaction of vancomycin and related antibiotics with trifluoroacetic acid at –15 °C for 40 h selectively cleaved the amino sugar vancosamine; the second sugar, glucose, was removed by reaction with trifluoroacetic acid at 50 °C for 3 h, and the N-terminal leucine moiety was cleaved using the Edman degradation procedure.