Can Sleeve Gastrectomy "Cure" Diabetes? Long-term Metabolic Effects of Sleeve Gastrectomy in Patients With Type 2 Diabetes
Can Sleeve Gastrectomy "Cure" Diabetes? Long-term Metabolic Effects of Sleeve Gastrectomy in Patients With Type 2 Diabetes
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DOI：
10.1097/sla.0000000000001857
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发表时间：
2016-10-01
影响因子：
9
通讯作者：
Schauer, Philip R.
中科院分区：
文献类型：
--
作者：
Aminian, Ali;Brethauer, Stacy A.;Schauer, Philip R.
目的：本研究的目的是评估腹腔镜袖状胃切除术（LSG）对2型糖尿病（T2 DM）患者的长期代谢影响，并确定长期糖尿病缓解和复发的预测因素。背景：LSG已成为全球最常见的减肥手术。然而，其对T2 DM患者的长期代谢影响尚不清楚。方法：对2005年至2010年期间在学术中心接受LSG并至少随访5年的134例肥胖T2 DM患者的结局进行评估。（范围：5-9），平均体重指数减轻-7.85.1kg/m2（2）（总重量损失：16.8%+/- 9.7%）与平均糖化血红蛋白降低相关（HbA 1c，-1.3 +/-1.8%，P < 0.001），空腹血糖（-37.8 +/-70.4mg/dL，P < 0.001）和糖尿病药物的中位数（-1，P < 0.001）。长期血糖控制（HbA 1c
Objective:The aim of the study was to assess long-term metabolic effects of laparoscopic sleeve gastrectomy (LSG) in patients with type 2 diabetes (T2DM) and to identify predictive factors for long-term diabetes remission and relapse.Background:LSG has become the most common bariatric operation worldwide. Its long-term metabolic effects in patients with T2DM are, however, unknown.Methods:Outcomes of 134 patients with obesity with T2DM who underwent LSG at an academic center during 2005 to 2010 and had at least 5 years of follow-up were assessed.Results:At a median postsurgical follow-up of 6 years (range: 5-9), a mean body mass index loss of -7.85.1kg/m(2) (total weight loss: 16.8%+/- 9.7%) was associated with a reduction in mean glycated hemoglobin (HbA1c, -1.3 +/- 1.8%, P < 0.001), fasting blood glucose (-37.8 +/- 70.4mg/dL, P < 0.001) and median number of diabetes medications (-1, P < 0.001). Long-term glycemic control (HbA1c