Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis
Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis
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DOI：
10.1007/s10735-013-9536-1
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发表时间：
2014-04-01
影响因子：
3.2
通讯作者：
Fan, Liqiao
中科院分区：
文献类型：
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作者：
Chen, Queting;Li, Yong;Fan, Liqiao
蛋白酪氨酸磷酸酶1B（PTP1B）是一种非跨膜蛋白酪氨酸磷酸酶，与癌症发病机制有关。然而，PTP1B的表达水平及其在结直肠癌（CRC）发生发展和预后中的作用尚不清楚。本研究采用免疫组化、实时定量PCR和Western blotting方法检测PTP1B在结直肠癌组织及癌旁组织中的表达。分析PTP1B表达水平与临床病理特征及患者生存期的相关性。我们发现，PTP1B的表达显着较高的CRC组织相比，匹配的非肿瘤组织。PTP1B表达与肿瘤分化程度、浸润深度、淋巴结转移、TNM分期有关。PTP1B高表达者生存率低（P = 0.012）。综上所述，我们的研究结果表明，PTP1B表达可能在CRC的进展中发挥关键作用，并可能作为CRC有价值的预后生物标志物。
Protein tyrosine phosphatase 1B (PTP1B) is a non-transmembrane protein tyrosine phosphatase that has been implicated in cancer pathogenesis. However, the expression level and the role of PTP1B in the development and prognosis of colorectal cancer (CRC) remain unclear. In this study, the expression of PTP1B in CRC tissues and matched noncancerous tissues were detected by using immunohistochemistry, real-time PCR and Western blotting. The correlations between PTP1B expression level and clinicopathologic characteristics and patient survival were analyzed. We found that PTP1B expression was significantly higher in CRC tissues compared with matched non-tumour tissues. Statistical analysis showed that the PTP1B expression was correlated with tumor differentiation, tumor invasion, lymph node metastasis, and TNM stage. Patients with higher expressions of PTP1B had the lower survival (P = 0.012). Taken together, our results suggest that PTP1B expression might play a critical role in the progression of CRC and may serve as a valuable prognostic biomarker for CRC.