Nicotine enhances sustained attention in the rat under specific task conditions
Nicotine enhances sustained attention in the rat under specific task conditions
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DOI：
10.1007/s002130050671
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发表时间：
1998-08-01
影响因子：
3.4
通讯作者：
Stolerman, IP
中科院分区：
文献类型：
--
作者：
Mirza, NR;Stolerman, IP
尽管尼古丁对动物和人类都有增强认知能力的作用，但大多数对人类的研究只显示出对持续注意力的持续改善。此外，许多针对吸烟者的研究都受到了批评，因为尼古丁可能只是缓解戒断所致的缺陷。本研究通过一个五选择系列反应时间任务，研究了尼古丁对未用药大鼠持续注意力的影响。最初，该任务被证明满足警觉性任务构造有效性的一些标准：减少信号长度，显著增加或减少试验间隔(P
Although nicotine has cognitive enhancing effects in both animals and humans, most studies in humans have only shown consistent Improvements in sustained attention. Moreover, many studies with smokers have been criticised, since nicotine may simply be relieving withdrawal-induced deficits. The present study investigated the effect of nicotine on sustained attention in drug-naive rats using a five-choice serial reaction time task. Initially, the task was demonstrated to satisfy some of the criteria for the construct validity of a vigilance task: reducing signal length and either increasing or decreasing the inter-trial interval significantly (P