The heritability of body mass index among an international sample of monozygotic twins reared apart.
The heritability of body mass index among an international sample of monozygotic twins reared apart.
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发表时间：
1996-06
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通讯作者：
D. B. Allison;J. Kaprio;M. Korkeila;M. Koskenvuo;M. Neale;K. Hayakawa
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作者：
D. B. Allison;J. Kaprio;M. Korkeila;M. Koskenvuo;M. Neale;K. Hayakawa
背景已发表的体重指数 (BMI) 遗传力估计 (h2) 范围从低至 0.05 到高至 0.90。本文的目的是引入新数据来帮助缩小合理估计的范围。受试者受试者为 53 对（23 M；30 F）分开抚养的同卵双胞胎 (MZA)，其平均 BMI 为 24.2 (SD = 4.7)。通过 Box-Cox 变换将 BMI 变换为近似正态。 Twin paris 来自芬兰双胞胎队列（17 对）、日本双胞胎数据库（10 对），并发布了主要是美国双胞胎（26 对）的病例史。结果 MZA 的 h2 由孪生对之间的相关性给出。对于转换后的数据，双胞胎 BMI 的零阶相关性为：所有双胞胎为 0.79，芬兰双胞胎为 0.63，日本双胞胎为 0.73，“档案”双胞胎为 0.85。当使用回归建模来控制相关协变量时，h2 的估计值为 0.50 或 0.70，具体取决于定义。半偏 r 为 0.50，表明在控制协变量后，BMI 总方差的 50% 似乎源于遗传。部分 r 为 0.70，表明协变量未解释的 BMI 方差中 70% 可归因于遗传变异。分居年龄与 BMI 的绝对配对内差异存在较小的正相关性，这表明 h2 的这些估计值不会因早期共享环境而出现向上偏差。结论 研究结果与过去的 MZAs 研究结果一致，表明 h2 估计值在 0.50 到 0.70 之间是合理的。讨论了这一发现的含义。
BACKGROUND Published heritability estimates (h2) for body mass index (BMI) range from as low as 0.05 to as high as 0.90. The purpose of this paper is to introduce new data to help narrow the range of plausible estimates. SUBJECTS Subjects were 53 pairs (23 M; 30 F) of monozygotic twins reared apart (MZAs), whose mean BMI was 24.2 (SD = 4.7). BMI's were transformed to approximate normality via the Box-Cox transformation. Twin paris came from the Finnish Twin Cohort (17 pairs), a data base of Japanese twins (10 pairs) and published case histories of primarily American twins (26 pairs). RESULTS The h2 for MZAs is given by the correlation among the twin pairs. For the transformed data, the zero-order correlation of twins' BMIs was 0.79 for all twins, 0.63 for the Finnish twins, 0.73 for the Japanese twins and 0.85 for the 'archival' twins. When modeled with regression to control for relevant covariates, the estimate of h2 is either 0.50 or 0.70, depending on one's definition. The semipartial r was 0.50, suggesting that 50% of the total variance in BMI appears to the genetic in origin after controlling the covariates. The partial r was 0.70, suggesting that 70% of the variance in BMI that is not accounted for by the covariates can be attributed to genetic variation. Separation age had a small positive correlation with absolute intra-pair difference in BMI, suggesting that these estimates of h2 are not biased upwards due to early shared environment. CONCLUSIONS Findings are consistent with past studies of MZAs and suggest that h2 estimates between 0.50 and 0.70 are reasonable. Implications of this finding are discussed.