Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach
Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach
复制标题
DOI：
10.1016/s0046-8177(99)90227-7
复制
发表时间：
1999-09-01
期刊：
影响因子：
3.3
通讯作者：
Weinstein, IB
中科院分区：
文献类型：
--
作者：
Arber, N;Gammon, MD;Weinstein, IB
细胞周期蛋白D1基因的高表达常见于人的食道鳞癌。然而，之前还没有详细研究过食管腺癌或胃腺癌中细胞周期蛋白D1的表达。因此，我们同时检测了食管鳞癌、腺癌和胃腺癌中细胞周期蛋白Dl的表达。应用免疫组织化学方法检测39例食管癌和34例胃癌组织中细胞周期蛋白D1的表达水平，并与临床病理参数进行相关性分析。在食管鳞癌中，71%的鳞癌和%的腺癌中细胞周期蛋白D1表达增强。胃腺癌的总阳性率为47%，贲门癌为44%，胃其他部位为50%。食管腺癌和胃肠型腺癌中，细胞周期蛋白D1阳性表达的比例为70%，而弥漫型仅为13%(P<0.01)。中位年龄67岁以上患者的肿瘤阳性率高于67岁以下患者(分别为74%和42%)(P<；.01)。高分化和中分化肿瘤的阳性率也高于低分化肿瘤(分别为74%和49%)(P<；0.05)。在不同类型的肿瘤中，有22%的肿瘤细胞周期蛋白D1胞浆染色。因此，在食管腺癌和鳞癌以及胃腺癌中，细胞周期蛋白D1的表达增加是常见的。腺癌中的高表达在肠型病变中尤为常见。Hum Pathol 30：1087-1092版权所有(C)1999年，W.B.桑德斯公司。
Increased expression of the cyclin D1 gene frequently occurs in human squamous carcinomas of the esophagus. However, the expression of cyclin D1 has not been previously examined in detail in adenocarcinomas of the esophagus or stomach. Therefore, we examined, in parallel, the expression of cyclin Dl in both squamous and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach. The level of expression of the cyclin D1 protein was assessed by immunohistochemistry in 39 esophageal and 34 gastric carcinomas and correlated with clinical and pathology parameters. Within the esophagus, 71% of the squamous carcinomas and 64% of the adenocarcinomas were positive for increased cyclin D1 nuclear staining. For adenocarcinomas of the stomach, the overall positive rate was 47%; in the gastric cardia, the rate was 44%, and in other regions of the stomach, it was 50%. In esophageal and gastric adenocarcinomas of the intestinal type, increased expression of cyclin D1 was seen in 70% of the samples, whereas with the diffuse type only 13% were positive (P < .01). Tumors from patients older than the median age of 67 years were more frequently positive than tamers from patients younger than 67 years (74% v 42%, respectively) (P < .01). Positive staining was also seen more frequently in well and moderately differentiated tumors than in poorly differentiated tumors (74% v 49%, respectively) (P < .05). Cytoplasmic staining for cyclin D1 was noted in 22% of the tumors, of various types. Therefore, increased expression of cyclin D1 frequently occurs in both adenocarcinomas and squamous carcinomas of the esophagus, and in adenocarcinomas of the stomach. The increased expression in adenocarcinomas is especially frequent in the intestinal-type lesions. HUM PATHOL 30:1087-1092 Copyright (C) 1999 by W.B. Saunders Company.