Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.
Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.
复制标题
有氧运动训练可降低老年人的脑血管阻抗：一项为期一年的随机对照试验。
DOI：
10.1152/japplphysiol.00241.2022
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhang,Rong
中科院分区：
文献类型：
--
作者：
Sugawara,Jun;Tarumi,Takashi;Xing,Changyang;Liu,Jie;Tomoto,Tsubasa;Pasha,EvanP;Zhang,Rong
老年人的脑血管阻抗高于年轻人，这可能是慢性脑血流灌注不足的原因之一。此外，中年运动员的脑血管阻抗低于久坐不动的同龄人。我们研究了有氧运动训练(AET)是否能降低久坐不动的老年人的脑血管阻抗。我们进行了一项概念验证试验，将73名老年人随机分为一年的AET(n=36)或拉伸和调理(SAT，n=37)干预。同时记录颈动脉压(CAP)和经颅多普勒(TCD)测定大脑中动脉血流速度(CBFV)，计算脑血管阻抗。56名参与者完成了为期一年的干预，其中41人完成了脑血管阻抗测量。AET组干预后V̇o2峰值[估计边际均值(95%可信区间)由22.821.6~24.1增至24.9mL.kg−1·cm−1，P<；0.001]，但Sat无明显变化[从21.7mL.kg−1·cm−1，P=0.114]。在0.78-3.12赫兹频率范围内，CBFV和CAP变化之间的一致性为>；0.90。该频段的平均脑血管阻抗模数(Z)在AET后1年下降[从1·05(0·96~1·14)至0·95(0·92~1·06)mm Hg·S·cm−1，P=0.023]，而SAT无明显变化[从0·96(0·87~1·04)至1·01(0·92~1·10)mm Hg·S·cm·−1，P=0.138]。AET组Z值下降与颈动脉脉压下降呈正相关(r=0.628，P=0.004)，与平均CBFV呈负相关(r=−0.563，P=0.012)。一年的AET降低了老年人的脑血管阻抗，这可能有利于脑灌流。脑血管阻抗的估计对于了解动态脑血流调节是必不可少的。这项随机对照试验表明，有氧运动训练降低了老年人的脑血管阻抗，这可能有利于脑灌流。
Older adults have higher cerebrovascular impedance than young individuals which may contribute to chronic brain hypoperfusion. Besides, middle-aged athletes exhibit lower cerebrovascular impedance than their sedentary peers. We examined whether aerobic exercise training (AET) reduces cerebrovascular impedance in sedentary older adults. We conducted a proof-of-concept trial that randomized 73 older adults to 1 yr of AET (n= 36) or stretching and toning (SAT,n= 37) interventions. Cerebrovascular impedance was estimated from simultaneous recordings of carotid artery pressure (CAP) via applanation tonometry and cerebral blood flow velocity (CBFV) in the middle cerebral artery via transcranial Doppler using transfer function analysis. Fifty-six participants completed 1-yr interventions, and 41 of those completed cerebrovascular impedance measurements. AET group showed a significant increase in V̇o2peakafter the intervention [estimated marginal mean (95% confidence interval); from 22.8 (21.6 to 24.1) to 24.9 (23.6 to 26.2) mL·kg−1·cm−1,P< 0.001], but not SAT [from 21.7 (20.5 to 22.9) to 22.3 (21.1 to 23.7) mL·kg−1·cm−1,P= 0.114]. Coherence between changes in CBFV and CAP was >0.90 in the frequency range of 0.78–3.12 Hz. The averaged cerebrovascular impedance modulus (Z) in this frequency range decreased after 1-yr AET [from 1.05 (0.96 to 1.14) to 0.95 (0.92 to 1.06) mmHg·s·cm−1,P= 0.023], but not SAT [from 0.96 (0.87 to 1.04) to 1.01 (0.92 to 1.10) mmHg·s·cm−1,P= 0.138]. Reductions inZwere correlated positively with reductions in carotid pulse pressure (r= 0.628,P= 0.004) and inversely with mean CBFV (r= −0.563,P= 0.012) in the AET group. One-year AET reduces cerebrovascular impedance in older adults, which may benefit brain perfusion.NEW & NOTEWORTHYEstimation of cerebrovascular impedance is essential for understanding dynamic cerebral blood flow regulation. This randomized controlled trial demonstrated that aerobic exercise training reduced cerebrovascular impedance in older adults, which may benefit brain perfusion.