PROGNOSTIC SIGNIFICANCE OF TUMOR EMBOLI IN INTRA-MAMMARY LYMPHATICS IN PATIENTS WITH MAMMARY-CARCINOMA
PROGNOSTIC SIGNIFICANCE OF TUMOR EMBOLI IN INTRA-MAMMARY LYMPHATICS IN PATIENTS WITH MAMMARY-CARCINOMA
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DOI：
10.1097/00000478-197701010-00003
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发表时间：
1977-01-01
影响因子：
5.6
通讯作者：
URBAN, JA
中科院分区：
文献类型：
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作者：
NIME, FA;ROSEN, PP;URBAN, JA
大约20%没有腋窝转移的浸润性乳腺癌患者在初始治疗的10年内发生复发癌。很明显，有必要确定这些患者最有可能在这组复发，因为他们可能受益于辅助治疗。本研究旨在评估无淋巴结转移的浸润性乳腺癌患者乳房内淋巴瘤栓的预后意义。1974年治疗的23例和1964年治疗的15例患者与对照组进行了比较，对照组没有淋巴栓塞。在1964年组中，大约43%的有淋巴结栓塞的患者和4%的无栓塞的患者随访5年或更长时间后发生了远处转移（p< 0.001）。在1964年和1974年的整个系列患者中，仅在一名研究患者和一名对照患者中发现局部复发。结果表明，在无腋窝转移的患者中，乳腺内淋巴间隙中发现肿瘤细胞与远处转移的实质性风险相关，但与局部复发无关。
Approximately 20% of patients with invasive mammary carcinoma who do not have axillary metastases develop recurrent carcinoma within 10 years of initial therapy. There is clearly a need to identify those patients most likely to develop recurrences in this group since they may benefit from adjuvant therapy. This study was undertaken to evaluate the prognostic significance of intramammary lymphatic tumor emboli in patients with invasive breast carcinoma who did not have lymph node metastases. Twenty-three such patients treated in 1974 and 15 from 1964 were compared with matched groups of control patients who did not have lymphatic emboli. About 43% of patients with lymphatic emboli and 4% of those without emboli followed for 5 or more years in the 1964 group developed distant metastases (p< 0.001). Local recurrences were found in only one study patient and one control in the entire series of 1964 and 1974 patients. The results suggest that among patients without axillary metastases, the finding of tumor cells in lymphatic spaces within the breast is associated with a substantial risk of distant metastases but not local recurrence.