Oscillatory Theta Activity during Memory Formation and Its Impact on Overnight Consolidation: A Missing Link?
Oscillatory Theta Activity during Memory Formation and Its Impact on Overnight Consolidation: A Missing Link?
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DOI：
10.1162/jocn_a_00804
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发表时间：
2015-08-01
影响因子：
3.2
通讯作者：
Schabus, Manuel
中科院分区：
文献类型：
--
作者：
Heib, Dominik P. J.;Hoedlmoser, Kerstin;Schabus, Manuel
睡眠已经被证明可以促进由某些振荡模式驱动的记忆巩固，例如睡眠纺锤波。然而，睡眠并不会统一地巩固所有新编码的信息，而是选择某些记忆进行巩固。据推测，这种选择取决于睡眠前附加到新记忆的显著性标签。然而，很少有人知道的潜在的神经元过程反映pressurememory标记。目前的研究试图解决的问题，是否事件相关的变化，光谱θ功率（θ ERSP）在pressurized记忆形成过程中可以反映记忆标记，影响随后的巩固在睡眠中。24名参与者在睡觉前记住160个单词对;在一个单独的实验室访问中，他们执行了一项非学习控制任务。在8小时睡眠前和8小时睡眠后，对记忆性能进行了两次测试。结果表明，与对照组相比，一夜之间提高记忆表现的参与者在记忆任务期间显示出更强的θ ERSP。他们还表现出更强的记忆任务相关的快速睡眠纺锤体活动的增加。此外，θ波前活动与快速睡眠纺锤波活动直接相关，这表明记忆形成过程可能确实反映了影响随后睡眠巩固的记忆标记。有趣的是，我们的研究结果进一步表明，睡眠纺锤波和夜间表现变化之间的关系并不像以前认为的那样直接。相反，它似乎是介导的过程中开始前记忆的形成。我们的结论是，θ ERSP在presthesive记忆形成反映皮质-海马的相互作用，导致一个更好的长期可访问性标记的记忆睡眠纺锤相关的再加工。
Sleep has been shown to promote memory consolidation driven by certain oscillatory patterns, such as sleep spindles. However, sleep does not consolidate all newly encoded information uniformly but rather selects certain memories for consolidation. It is assumed that such selection depends on salience tags attached to the new memories before sleep. However, little is known about the underlying neuronal processes reflecting presleep memory tagging. The current study sought to address the question of whether event-related changes in spectral theta power (theta ERSP) during presleep memory formation could reflect memory tagging that influences subsequent consolidation during sleep. Twenty-four participants memorized 160 word pairs before sleep; in a separate laboratory visit, they performed a nonlearning control task. Memory performance was tested twice, directly before and after 8 hr of sleep. Results indicate that participants who improved their memory performance overnight displayed stronger theta ERSP during the memory task in comparison with the control task. They also displayed stronger memory task-related increases in fast sleep spindle activity. Furthermore, presleep theta activity was directly linked to fast sleep spindle activity, indicating that processes during memory formation might indeed reflect memory tagging that influences subsequent consolidation during sleep. Interestingly, our results further indicate that the suggested relation between sleep spindles and overnight performance change is not as direct as once believed. Rather, it appears to be mediated by processes beginning during presleep memory formation. We conclude that theta ERSP during presleep memory formation reflects cortico-hippocampal interactions that lead to a better long-term accessibility by tagging memories for sleep spindle-related reprocessing.