Recovery of oxygen utilization efficiency after global myocardial ischemia.
Recovery of oxygen utilization efficiency after global myocardial ischemia.
复制标题
全心肌缺血后氧利用效率的恢复。
DOI：
10.1016/0003-4975(91)91283-2
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
EdmundsJr,LH
中科院分区：
文献类型：
--
作者：
Furukawa,S;Kreiner,G;Bavaria,JE;Streicher,JT;EdmundsJr,LH
在15只绵羊上研究了热缺血12分钟后心肌氧利用恢复所需的时间。五只对照动物在37 °C下进行了42分钟的心肺转流，心脏跳动并排气。在10只实验动物中，在心脏通气的情况下，在旁路期间将主动脉夹闭12分钟，并且在移除夹后再灌注动物30分钟。在两组中，在体外循环结束后30分钟和每小时测量左心室冠状动脉血流量、耗氧量（LVO 2）、峰值收缩压、周向收缩应力积分（CSI）和压力容积面积（PVA），持续5小时。可逆性缺血显著增加LVO 2/PVA和LVO 2/ CSI之间的关系1小时后，钳夹被释放，但关系恢复到旁路前的值2小时。缺血显著降低收缩末期弹性，此后仍保持抑制。无心肌缺血的心脏搭桥术显著降低工作羊心脏的总心室机械能输出和氧利用效率，但不显著改变收缩末期弹性或LVO 2/ PVA和LVO 2/CSI关系。12分钟的热缺血损害再灌注羊心脏的氧利用效率超过60分钟，但小于120分钟。
The time required for myocardial oxygen utilization to recover from 12 minutes of warm ischemia was studied in 15 sheep. Five control animals had 42 minutes of cardiopulmonary bypass at 37 °C with the heart beating and vented. In 10 experimental animals, the aorta was clamped for 12 minutes during bypass with the heart vented, and the animals were perfused 30 additional minutes after removal of the clamp. In both groups, measurements of left ventricular coronary arterial blood flow, oxygen consumption (LVO2), peak systolic pressure, circumferential systolic stress integral (CSI), and pressure volume area (PVA) were made 30 minutes after and hourly for 5 more hours after cardiopulmonary bypass ended. Reversible ischemia significantly increases the relationship between LVO2/PVA and LVO2/ CSI 1 hour after the clamp is released, but the relationships return to prebypass values by 2 hours. Ischemia significantly decreases end-systolic elastance, which remains depressed thereafter. Cardiopulmonary bypass without myocardial ischemia significantly decreases total ventricular mechanical energy output and oxygen utilization efficiency of the working sheep heart but does not significantly alter end-systolic elastance or the LVO2/ PVA and LVO2/CSI relationships. Twelve minutes of warm ischemia impairs oxygen utilization efficiency in the reperfused sheep heart for more than 60 minutes but less than 120 minutes.