Associations between single-nucleotide polymorphisms (+45T>G,+276G>T,-11377C>G,-11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis
Associations between single-nucleotide polymorphisms (+45T>G,+276G>T,-11377C>G,-11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis
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DOI：
10.1007/s00125-011-2202-9
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发表时间：
2011-09-01
期刊：
影响因子：
8.2
通讯作者：
Sun, H.
中科院分区：
文献类型：
--
作者：
Han, L. Y.;Wu, Q. H.;Sun, H.
脂联素多态性与2型糖尿病之间的关系已被广泛研究；然而，结果并不一致。我们检索了电子文献数据库和相关文章的参考书目。在异质性的基础上，采用固定或随机效应模型。进行亚组和元回归分析以探索异质性的来源。+45T b> G （rs2241766）、+276G > T （rs1501299）、-11391G > A （rs17300539）与2型糖尿病风险无统计学意义。然而，对于-11377C > G (rs266729)， G与C等位基因的合并OR （95% CI）为1.07 （1.03-1.11,p = 0.001）。研究设计的亚组分析显示，在基于人群的病例对照研究中，-11377C > G （rs266729）显性模型（CG+GG vs CC, p = 0.0008）和G vs C等位基因（p = 0.0004）可能与2型糖尿病风险相关。在种族分层后，我们发现-11377C > G （rs266729）显性模型（CG+GG vs CC, p = 0.004）和G vs C等位基因（p = 0.001）可能与白人2型糖尿病风险相关。在有糖尿病家族史的个体中，-11391G b> a （rs17300539）显性模式（GA+AA vs GG）和a vs G等位基因的存在可能与2型糖尿病风险增加有关。+45T b> G （rs2241766）、+276G > T （rs1501299）和-11391G > A （rs17300539）的存在似乎不影响2型糖尿病的发展。然而，G vs C等位基因-11377C > G （rs266729）可能是2型糖尿病的危险因素。
The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent.We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity.There were no statistically significant associations between +45T > G (rs2241766), +276G > T (rs1501299), -11391G > A (rs17300539) and type 2 diabetes risk. However, for -11377C > G (rs266729), the pooled OR (95% CI) for G vs C allele was 1.07 (1.03-1.11, p = 0.001). Subgroup analysis by study design revealed that -11377C > G (rs266729) dominant model (CG+GG vs CC, p = 0.0008) and G vs C allele (p = 0.0004) might be associated with type 2 diabetes risk in population-based case-control studies. After stratification by ethnicity, we found that -11377C > G (rs266729) dominant model (CG+GG vs CC, p = 0.004) and G vs C allele (p = 0.001) might be associated with type 2 diabetes risk in white individuals. In individuals with a family history of diabetes, the presence of -11391G > A (rs17300539) dominant model (GA+AA vs GG) and A vs G allele might be associated with increased risk of type 2 diabetes.The presence of +45T > G (rs2241766), +276G > T (rs1501299) and -11391G > A (rs17300539) do not appear to influence the development of type 2 diabetes. However, G vs C allele of -11377C > G (rs266729) might be a risk factor for type 2 diabetes.