The prealbumin nature of the amyloid protein in familial amyloid polyneuropathy (FAP)-swedish variety.
The prealbumin nature of the amyloid protein in familial amyloid polyneuropathy (FAP)-swedish variety.
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家族性淀粉样多发性神经病（FAP）瑞典品种中淀粉样蛋白的前白蛋白性质。
DOI：
10.1016/0006-291x(81)90764-6
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发表时间：
1981
影响因子：
3.1
通讯作者：
Cohen,AS
中科院分区：
文献类型：
--
作者：
Skinner,M;Cohen,AS
家族性淀粉样多发性神经病（FAP）是淀粉样变性的一种主要遗传类型，影响许多国家的亲属关系。我们已经从一名瑞典家族性淀粉样多发性神经病患者的淀粉样组织中分离出一种道尔顿的蛋白质。通过N-末端序列分析，其与正常血浆蛋白前白蛋白同源。针对分离的蛋白质制备的抗血清通过与淀粉样蛋白和前白蛋白的相同反应证实了这一点。正常的血浆蛋白，前白蛋白，第一次与疾病综合征联系起来。
Familial amyloid polyneuropathy (FAP) is a dominant hereditary type of amyloidosis affecting kinships originating in many countries. We have isolated a 15,000 dalton protein from the amyloid laden tissue of a patient of Swedish origin with familial amyloid polyneuropathy. By N-terminal sequence analysis it is homologous to the normal plasma protein, prealbumin. An antiserum prepared to the isolated protein confirms this by reacting identically with the amyloid protein and prealbumin. The normal plasma protein, prealbumin, is linked to a disease syndrome for the first time.