The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments.
The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments.
复制标题
神经视网膜的背腹轴分为多个受限基因表达域，表现出谱系区室的特征。
DOI：
10.1006/dbio.2002.0791
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发表时间：
2002
影响因子：
2.7
通讯作者：
Cepko,ConstanceL
中科院分区：
文献类型：
--
作者：
Peters,MaureenA;Cepko,ConstanceL
神经视网膜是一个复杂的感觉结构，用于接收、整合和传递视觉信息。视网膜发育的一个重要方面是沿背腹轴（D-V）和前后轴（A-P）建立模式。最近对背侧特异性和腹侧特异性转录因子的鉴定和功能表征表明，D-V轴分为两个结构域。这项研究表征了这些和其他D-V标记的表达模式，并确定视网膜沿着这条轴被细分为至少四个基因表达域。这些表达域的组成和空间关系改变了我们的D-V模式模型，表明视网膜模式的方式比以前认识到的更复杂。由于发育组织内的基因表达域有时包含不被克隆相关细胞跨越的区室，我们进行了逆转录病毒谱系研究。观察到细胞强烈倾向于保持在其原始基因表达域，这表明这些边界包括发育区室。
The neural retina is a complex sensory structure designed to receive, integrate, and transmit visual information. An important aspect of retinal development is the establishment of pattern along the dorsal–ventral (D-V) and anterior–posterior (A-P) axes. The recent identification and functional characterization of a dorsal-specific and a ventral-specific transcription factor suggested that the D-V axis is divided into two domains. This study characterizes the expression patterns of these and other D-V markers, and establishes that the retina is subdivided into at least four domains of gene expression along this axis. The composition and spatial relation of these expression domains alters our model of D-V patterning, suggesting more complexity in the way that the retina is patterned than was previously recognized. As domains of gene expression within developing tissues sometimes comprise compartments whose borders are not crossed by clonally related cells, we performed a retroviral lineage study. A strong preference for cells to remain in their original domain of gene expression was observed, suggesting that these borders comprise developmental compartments.