Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.
Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.
复制标题
hTERT 前体 mRNA 的选择性剪接：端粒酶活性调节的潜在策略
DOI：
10.3390/ijms18030567
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发表时间：
2017-03-07
影响因子：
5.6
通讯作者：
Geng X
中科院分区：
文献类型：
--
作者：
Liu X;Wang Y;Chang G;Wang F;Wang F;Geng X
端粒酶的激活是细胞恶性转变的关键事件之一，在激活termerase的过程中，人端粒酶逆转录酶（HTERT）的表达是必不可少的。水平是调节端粒酶活性的机制之一。型特定方式。相关疾病。该综述着重于HTERT前MRNA替代剪接及其生物学功能的模式，描述端粒酶活性，并讨论了HTERT前MRNA替代剪接在癌症和与衰老相关疾病的诊断，治疗和预后中的替代剪接的可能意义。
The activation of telomerase is one of the key events in the malignant transition of cells, and the expression of human telomerase reverse transcriptase (hTERT) is indispensable in the process of activating telomerase. The pre-mRNA alternative splicing of hTERT at the post-transcriptional level is one of the mechanisms for the regulation of telomerase activity. Shifts in splicing patterns occur in the development, tumorigenesis, and response to diverse stimuli in a tissue-specific and cell type–specific manner. Despite the regulation of telomerase activity, the alternative splicing of hTERT pre-mRNA may play a role in other cellular functions. Modulating the mode of hTERT pre-mRNA splicing is providing a new precept of therapy for cancer and aging-related diseases. This review focuses on the patterns of hTERT pre-mRNA alternative splicing and their biological functions, describes the potential association between the alternative splicing of hTERT pre-mRNA and telomerase activity, and discusses the possible significance of the alternative splicing of the hTERT pre-mRNA in the diagnosis, therapy, and prognosis of cancer and aging-related diseases.