ANTIVIRAL AGENTS .2. STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS RELATED TO 1-ADAMANTANAMINE
ANTIVIRAL AGENTS .2. STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS RELATED TO 1-ADAMANTANAMINE
复制标题
DOI：
10.1021/jm00288a019
复制
发表时间：
1971-01-01
影响因子：
7.3
通讯作者：
WATTS, JC
中科院分区：
文献类型：
--
作者：
ALDRICH, PE;HERMANN, EC;WATTS, JC
(6)W. L.温菲尔德，D. Pollack，and RR Grunert，N. Engl.医学杂志，281，579（1969）中。盐酸金刚乙胺（a-甲基-l-金刚烷-甲胺· HCl，58）用于自然发生的甲型流感呼吸道疾病患者。对风疹病毒、7型劳斯肉瘤病毒、8· 9型劳斯肉瘤病毒和Esh肉瘤病毒也有抑制作用。盐酸金刚烷胺最近被证明对帕金森病患者有益。10与此同时，其他人11已经公开了包含金刚烷部分的药物的结果。1-金刚烷胺的结构变异对抗病毒活性的影响尚无系统的研究（7）（a）KW Cochran和HF Maassab，Fed.程序，Fed.美国社会科学院生物学：23，387（1964）;（B）A. Tsunoda，HF Maassab，KW Cochran和W. E.伊芙兰，抗菌剂。AG. Chemother.，第553（1965）号来文。(8)N. Oker-Blom和AL安德森，Eur. J. Cancer，2，9（1966）. (9)A. M. Wallbank，RE Matter，and NG Klinikowski，Science，152，1760（1966）.
(6) W. L. Wingfield, D. Pollack, and RR Grunert, N. Engl. J. Med., 281, 579 (1969). and with rimantadine· HCl6 (a-methyl-l-adamantane-methylamine· HCl, 58) in patients with natu-rally occurring influenza A2 respiratory illness. Inhibi-tion of rubella, 7 Rous sarcoma, 8· 9 and Esh sarcoma viruses has also been reported. Amantadine· HCl more recently has been demonstrated to benefit pa-tients suffering from Parkinson’s disease. 10 Meanwhile, others11 have disclosed results from drugs that include the adamantane moiety. No systematic study of the effect of structural varia-tions of 1-adamantanamine upon antiviral activity has (7)(a) KW Cochran and HF Maassab, Fed. Proc., Fed. Amer. Soc. Exp. Biol., 23, 387 (1964);(b) A. Tsunoda, HF Maassab, KW Cochran, and W. E. Eveland, Antimicrob. Ag. Chemother., 553 (1965).(8) N. Oker-Blom and AL Anderson, Eur. J. Cancer, 2, 9 (1966).(9) A. M. Wallbank, RE Matter, and NG Klinikowski, Science, 152, 1760 (1966).