Renal transport of organic anions
Renal transport of organic anions
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有机阴离子的肾脏转运
DOI：
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发表时间：
1998
影响因子：
3.2
通讯作者：
F. Roch
中科院分区：
文献类型：
--
作者：
F. Roch
本文综述了不同的运输机制介导的根尖和基底侧的有机阴离子的运输，所有这些都局限于近端小管。几种转运机制，如对氨基马蹄铁基底外侧转运体和根尖质子偶联二肽和三肽转运体已被克隆，它们在肾脏转运中的作用已被很好地表征。其他转运蛋白已经从肾脏、肝脏或肠道中克隆出来，但它们在有机阴离子的肾脏转运中的作用需要阐明。这是Mdr2， oatpl和OAT-K1，它们在近端小管的顶膜中被发现，而MDR1，其精确定位仍不确定。有机阴离子重吸收还涉及其他的顶端转运机制，钠偶联转运和阴离子交换剂。
This review deals with the different transport mechanisms mediating the apical and basolateral transport of organic anions, all of which are restricted to the proximal tubule. Several transport mechanisms, such as the para-aminohippurate basolateral transporter and the apical proton coupled di- and tripeptide transporter have been cloned, and their role in renal transport has been well characterized. Other transport proteins have been cloned from the kidney, liver, or intestine, but their role in the renal transport of organic anions needs to be elucidated. This is the with Mdr2, oatpl and OAT-K1, which were identified in the apical membrane of the proximal tubule, and with MDR1, the precise localization of which is still uncertain. Other apical transport mechanisms, sodium coupled transports and anion exchangers are involved in organic anion reabsorption.
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影响因子：
2.9
作者：
Fei, YJ;Liu, W;Leibach, FH
通讯作者：
Leibach, FH
影响因子：
19.6
作者：
RYAN, MJ;JOHNSON, G;TOROKSTORB, B
通讯作者：
TOROKSTORB, B
纯化的近端小管阴离子交换蛋白的功能特性：介导氯离子/甲酸盐和氯离子/碳酸氢盐交换。
影响因子：
19.6
作者：
Soleimani,M;Bizal,GL
通讯作者：
Bizal,GL
影响因子：
15.9
作者：
Lu, R;Kanai, N;Schuster, VL
通讯作者：
Schuster, VL