Clinical and sexual risk correlates of Mycoplasma genitalium in urban pregnant and non-pregnant young women: cross-sectional outcomes using the baseline data from the Women's BioHealth Study
Clinical and sexual risk correlates of Mycoplasma genitalium in urban pregnant and non-pregnant young women: cross-sectional outcomes using the baseline data from the Women's BioHealth Study
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DOI：
10.1136/sextrans-2017-053367
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发表时间：
2018-09-01
影响因子：
3.6
通讯作者：
Gaydos, Charlotte A.
中科院分区：
文献类型：
--
作者：
Trent, Maria;Coleman, Jenell S.;Gaydos, Charlotte A.
目的探讨生殖支原体（MG）的临床与性风险相关因素，为制定生殖支原体筛查与管理的通用标准提供依据。本研究的目的是利用横断面数据确定MG的基线患病率和相关的临床风险。方法对13 ~ 29岁的青少年和年轻成年女性进行临床访视，采集生物标本进行淋病奈瑟球菌（NG）和沙眼衣原体（CT）检测，为阴道MG和阴道毛滴虫（TV）检测提供阴道标本。在获得书面同意后收集人口统计、临床和性风险数据。MG检测采用Hologic GenProbe转录介导扩增-MG分析特异性试剂法，TV检测采用Aptima TV法。采用双变量分析来评估基于妊娠状况、人口统计学因素、临床症状、并发性传播感染和性危险行为测验得分（最高得分=10）的MG患病率差异。结果纳入483例患者，平均年龄22.4岁（SD 3.6）。大多数参与者没有怀孕（66%）和无症状（59%）。MG是最常见的STI （MG 16%, TV 9%, CT 8%, NG 1%）。怀孕和症状都不能预测性传播感染阳性。35%的未怀孕少女和45%的怀孕少女= 19岁的性传播感染呈阳性。MG患者合并其他性传播感染的可能性是合并其他性传播感染者的3.4倍（OR 3.4, 95% CI 1.17 ~ 10.3， P= 0.021）。性传播感染阳性妇女的平均风险测验得分比性传播感染阴性妇女高6分（ss= 0.63, 95% CI 0.36至0.90，P< 0.001）。mg阳性受试者与其他STI阳性受试者的风险评分没有差异。结论MG感染较为常见，与性传播感染合并感染有关，且多无症状，妊娠状态不具有保护作用。
Objective R esearch exploring the clinical and sexual risk correlates is essential to define universal standards for screening and management for Mycoplasma genitalium (MG). The objective of this study is to determine the baseline prevalence of MG and associated clinical risks using cross-sectional data.Methods Adolescent and young adult women 13-29 years were recruited during clinical visits during which biological specimens were collected for Neisseriagonorrhoeae (NG) and Chlamydia trachomatis (CT) testing to provide vaginal specimens for MG and Trichomonasvaginalis (TV) testing. Demographic, clinical and sexual risk data were collected after obtaining written consent. MG was tested using the Hologic GenProbe transcription-mediated amplification-MG analytespecific reagent assay and TV by the Aptima TV assay. Bivariate analyses were used to evaluate differences in MG prevalence based on pregnancy status, demographic factors, clinical symptoms, concurrent STI and sexual risk behaviour quiz score (maximum score=10).Results 483 patients with a mean age of 22.4 years (SD 3.6) were enrolled. Most participants were not pregnant (66%) and asymptomatic (59%). MG was the most common STI (MG 16%, TV 9%, CT 8%, NG 1%). Neither pregnancy nor symptoms were predictive of STI positivity. Thirty-five percent of non-pregnant and 45% of pregnant adolescents = 19 years were positive for any STI. Participants with MG were 3.4 times more likely to be co-infected with other STIs compared with those with other STIs (OR 3.4, 95% CI 1.17 to 10.3, P= 0.021). Mean risk quiz scores for STI positive women were six points higher than those who were STI negative (ss= 0.63, 95% CI 0.36 to 0.90, P< 0.001). There were no differences in risk scores for MG-positive participants compared with other STI positivity.Conclusion MG infection was common, associated with STI co-infection and often asymptomatic, and pregnancy status did not confer protection.