Identification of Novel ARF Binding Proteins by Two-Hybrid Screening
Identification of Novel ARF Binding Proteins by Two-Hybrid Screening
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DOI：
10.4161/cc.5.6.2560
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发表时间：
2006-03
期刊：
影响因子：
4.3
通讯作者：
V. Tompkins;Jussara Hagen;Valerie P. Zediak;D. Quelle
中科院分区：
文献类型：
--
作者：
V. Tompkins;Jussara Hagen;Valerie P. Zediak;D. Quelle
ARF 肿瘤抑制因子通过部分定义的 p53 依赖性和 p53 独立途径中的蛋白质-蛋白质相互作用来保护我们免受癌症的侵害。我们使用 ARF 作为诱饵进行了双杂交筛选，并鉴定了几种可能调节其生长抑制信号传导的新 ARF 伙伴。讨论了这些新型 ARF 结合蛋白在调节 ARF 信号传导中的潜在生理作用。
The ARF tumor suppressor protects us against cancer through protein-protein interactionsin partially defined p53-dependent and p53-independent pathways. We performed a two-hybridscreen using ARF as bait and present the identification of several new ARF partners that mayregulate its growth inhibitory signaling. The potential physiological roles of these novel ARFbinding proteins in regulating ARF signaling are discussed.