Quantifying Hemodynamic Changes in Moyamoya Disease Based on Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging and Computational Fluid Dynamics.
Quantifying Hemodynamic Changes in Moyamoya Disease Based on Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging and Computational Fluid Dynamics.
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DOI：
10.1016/j.wneu.2018.09.057
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发表时间：
2018-12
影响因子：
2
通讯作者：
Wenbo Sun;Zhao Ruan;X. Dai;Sirui Li;Shuo Li;Jianjian Zhang;Jincao Chen;Heye Zhang;Haibo Xu
中科院分区：
文献类型：
--
作者：
Wenbo Sun;Zhao Ruan;X. Dai;Sirui Li;Shuo Li;Jianjian Zhang;Jincao Chen;Heye Zhang;Haibo Xu
ObjectiveTo investigate hemodynamic changes in moyamoya disease (MMD) via two-dimensional cine phase-contrast magnetic resonance imaging and computational fluid dynamics.MethodsIn 18 patients with MMD and 10 healthy control subjects, phase-contrast magnetic resonance imaging was performed to quantify flow rate of main supplying arteries, including internal carotid arteries (ICAs) and vertebral arteries. Mean flow rate in these vessels was adopted as the patient-specific boundary condition for computational fluid dynamics simulation of the circle of Willis in MMD and control groups. Pressure drop in both ICAs and their difference, wall shear stress and secondary flow in the carotid siphon of ICAs, and flow rate and size of posterior communicating arteries (PComAs) were compared between MMD and control groups. Four patients with MMD underwent follow-up scans for longitudinal comparison.ResultsPhase-contrast magnetic resonance imaging data revealed significantly different flow rate in the left ICA and right vertebral arteries between MMD and control groups. Computational fluid dynamics simulation demonstrated similar wall shear stress and similar secondary flow of both ICAs but significantly higher pressure drop in left ICA, higher pressure drop difference between left ICA and right ICA, and higher flow rate in PComAs in patients with MMD compared with control subjects. Significantly increased size of left PComA in patients with MMD was also found. Follow-up results confirmed that the combination of pressure drop difference, flow rate, and size of PComAs can potentially assist long-term prognosis after surgery.ConclusionsPressure drop difference, flow rate, and size of PComAs can be used to evaluate impairments in cerebrovascular reserve and indicate long-term prognosis in MMD.
