Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites
Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites
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DOI：
10.3390/nu11051017
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发表时间：
2019-05-01
期刊：
影响因子：
5.9
通讯作者：
Zou, Yuxiao
中科院分区：
文献类型：
--
作者：
Li, Qian;Liu, Fan;Zou, Yuxiao
从肠道微生态学和代谢组学角度分析桑葚成分减肥的分子机制。通过高热量饮食喂养大鼠建立肥胖模型。将大鼠分为肥胖模型对照组（MC）、阳性对照组（PC）、桑葚粉组（MLP）、桑葚纤维组（MLF）、桑葚多酚组（MLPS）、桑葚纤维多酚混合物组（MLM）和正常对照组（NC），连续6周。结果表明，MLM组的减肥效果最好，表明MLPS和MLF之间存在协同作用。厚壁菌门丰度的减少和下游的梭菌目（Lachnespiraceae）是减肥作用的关键途径。乳酸杆菌含量的增加可能导致脂质代谢紊乱。与MC组和NC组相比，试验组可将氨基酸和寡肽代谢紊乱调节至正常水平。
The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. The results demonstrated that the MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups.