Interferon-induced depressive illness in hep C patients responds to SSRI antidepressant treatments.
Interferon-induced depressive illness in hep C patients responds to SSRI antidepressant treatments.
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DOI：
10.2147/nedt.2006.2.3.355
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发表时间：
2006-09-01
影响因子：
3.2
通讯作者：
Bassett, Mark
中科院分区：
文献类型：
--
作者：
Gupta, Ramesh K;Kumar, Rajeev;Bassett, Mark
本文探讨了选择性5-羟色胺再摄取抑制剂（SSRIs）在治疗丙型肝炎病毒（HCV）患者谁开发干扰素-α诱导抑郁症的作用。HCV精神科联络诊所的2年数据分析已经进行。本文报告了用α-干扰素（INF-α）治疗的患者的诊断、治疗和进展。在HCV诊所登记并接受INF-α治疗的78例患者中，有53例被转诊接受精神科咨询。6例患者在INF治疗后出现重度抑郁症。他们都接受了SSRIs治疗，并完全康复。这是一个重要的观察结果，与其他研究一致。它的生化后果。它的结论是，INF诱导的抑郁症是完全可逆的。提出了一种假设，即SSRIs可能通过抑制犬尿氨酸途径的吲哚-2，3-双加氧酶诱导来调节神经保护性神经毒性比率。
This paper examines the role of selective serotonin reuptake inhibitors (SSRIs) in the treatment of hepatitis-C virus (HCV) patients who have developed interferon-alpha induced depression. A 2-year data analysis of HCV psychiatric liaison clinic has been undertaken. The diagnosis, treatment, and progress of those patients who were treated with interferon-alpha (INF-alpha) are reported. 53 of the 78 patients enrolled at the HCV Clinic and treated with INF-alpha were referred for psychiatric consultation. Six patients developed major depressive illness following INF therapy. They were all treated with SSRIs and they made full recovery. This is a significant observation and is concordant with other studies. Its biochemical ramifications are presented. It is concluded that INF-induced depression is fully reversible. A hypothesis is proposed that SSRIs modulate the neuro-protective neurotoxic ratio by possibly inhibiting the indole-2,3-dioxygenase induction of the kynurenine pathway.