CLONING AND MOLECULAR CHARACTERIZATION OF THE MURINE HERPESVIRUS 68 GENOME
CLONING AND MOLECULAR CHARACTERIZATION OF THE MURINE HERPESVIRUS 68 GENOME
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DOI：
10.1099/0022-1317-71-6-1355
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发表时间：
1990-06-01
影响因子：
3.8
通讯作者：
MINSON, AC
中科院分区：
文献类型：
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作者：
EFSTATHIOU, S;HO, YM;MINSON, AC
鼠疱疹病毒68 （MHV-68）是一种自然发生的小型自由生活啮齿动物的疱疹病毒。为了便于对病毒基因组进行分子表征，我们制作了一个克隆限制性内切片段文库，并推导出BamHI、EcoRI和HindIII酶的限制性内切酶切割图谱。MHV-68基因组包括一个大约118 kbp的独特DNA区域，其两侧有可变数量的1.23 kb重复单元。因此，MHV-68基因组的组织结构与嗜淋巴性γ最为相似。2组疱疹病毒，包括猴疱疹病毒和猴疱疹病毒。
Murine herpesvirus 68 (MHV-68) is a naturally occurring herpesvirus of small free-living rodents. In order to facilitate the molecular characterization of the virus genome, a library of cloned restriction fragments has been produced and restriction enzyme cleavage maps deduced for the enzymes BamHI, EcoRI and HindIII. The MHV-68 genome comprises a region of unique DNA of approximately 118 kbp which is flanked by variable numbers of a 1.23 kb repeat unit. The organization of the MHV-68 genome is, therefore, most similar to that of the lymphotropic .gamma.2 group of herpesviruses which include herpesvirus saimiri and herpesvirus ateles.