Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans
Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans
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DOI：
10.1086/588384
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发表时间：
2008-06-15
影响因子：
6.4
通讯作者：
Graviss, Edward A.
中科院分区：
文献类型：
--
作者：
Austin, Celest M.;Ma, Xin;Graviss, Edward A.
模式识别受体（PRR）在针对细胞内细菌的先天免疫中发挥着关键作用。 NOD2 是有助于结核分枝杆菌感染免疫反应的 PRR 之一。我们对 377 名患有结核病 (TB) 疾病的非裔美国人和 187 名种族匹配的对照受试者的 NOD2 基因编码区进行了测序。三种常见的非同义单核苷酸多态性——Pro268Ser、Arg702Trp 和 Ala725Gly——显示出与结核病的显着关联。这一发现可能有助于结核病免疫治疗和免疫预防的未来发展。
Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms-Pro268Ser, Arg702Trp, and Ala725Gly-demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.