A limited renal injury may cause a permanent form of neurogenic hypertension.
A limited renal injury may cause a permanent form of neurogenic hypertension.
复制标题
有限的肾损伤可能会导致永久性的神经源性高血压。
DOI：
10.1016/s0895-7061(98)00030-2
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发表时间：
1998
影响因子：
3.2
通讯作者：
Campese,VM
中科院分区：
文献类型：
--
作者：
Ye,S;Gamburd,M;Mozayeni,P;Koss,M;Campese,VM
此前，我们已经证明，肾内注射苯酚对肾脏造成的急性损伤会导致血压立即升高，并导致下丘脑后部去甲肾上腺素（NE）分泌增加。研究表明，在该模型中，从肾脏到大脑中枢整合结构的传入冲动可能是血压升高的原因。为了进一步评估肾内注射苯酚引起的肾损伤是否会导致血压永久性升高，以及这是否是由交感神经系统活动增加介导的，我们检查了肾内注射 50 μL 10% 苯酚对血压和后脑 NE 分泌的慢性影响（4 周）接受肾内注射苯酚 4 周后，收缩压从 128 ± 2.1 增加至 176 ± 1.5 mm Hg (P< .01)，但在接受媒介物的大鼠（128 ± 2.4 和 135 ± 1.7 mm Hg）和接受肾去神经支配的大鼠（127 ± 3.4 和 124）中收缩压没有变化± 1.0 毫米汞柱）。接受苯酚的大鼠 (253 ± 9.6 pg/mL) 的下丘脑后核的 NE 分泌量高于对照组 (158 ± 8.6 pg/mL) 和去神经大鼠 (170 ± 2.1 pg/mL)。这些研究表明，一侧肾脏的有限损伤可能导致血压永久性升高，这与交感神经系统活动增加有关。
Previously, we have shown that an acute injury to the kidney produced by an intrarenal injection of phenol causes an immediate increase in blood pressure and in norepinephrine (NE) secretion from the posterior hypothalamus. The studies suggest that in this model afferent impulses from the kidney to central integrative structures in the brain may be responsible for the increase in blood pressure.To further evaluate whether a renal injury caused by the intrarenal injection of phenol leads to a permanent elevation of blood pressure and whether this is mediated by increased sympathetic nervous system activity, we examined the chronic effects (4 weeks) of an intrarenal injection of 50 μL of 10% phenol on blood pressure and NE secretion from the posterior hypothalamus.Systolic blood pressure increased from 128 ± 2.1 to 176 ± 1.5 mm Hg (P< .01) 4 weeks after receiving the intrarenal injection of phenol, but it did not change in rats that received the vehicle (128 ± 2.4 and 135 ± 1.7 mm Hg) and in rats that were subjected to renal denervation (127 ± 3.4 and 124 ± 1.0 mm Hg). The secretion of NE from the posterior hypothalamic nuclei was greater (P< .01) in rats that received phenol (253 ± 9.6 pg/mL) than in controls (158 ± 8.6 pg/mL) and denervated rats (170 ± 2.1 pg/mL).These studies have shown that a limited injury to one kidney may cause a permanent elevation of blood pressure and this is associated with increased sympathetic nervous system activity.