Inhibition of the SERCA Ca2+ pumps by curcumin -: Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP
Inhibition of the SERCA Ca2+ pumps by curcumin -: Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP
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DOI：
10.1046/j.0014-2956.2001.02589.x
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发表时间：
2001-12-01
期刊：
影响因子：
--
通讯作者：
Michelangeli, F
中科院分区：
文献类型：
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作者：
Bilmen, JG;Khan, SZ;Michelangeli, F
姜黄素是一种从香料姜黄中提取的化合物。它是SERCA Ca2+泵（所有亚型）的有效抑制剂，抑制Ca2+依赖性ATP酶活性，IC 50值在7和15 μ M之间。它还抑制各种微粒体膜中ATP依赖性的Ca 2+摄取，尽管对于小脑和血小板微粒体，在低姜黄素浓度下观察到Ca 2+摄取的刺激（
Curcumin is a compound derived from the spice, tumeric. It is a potent inhibitor of the SERCA Ca2+ pumps (all isoforms), inhibiting Ca2+-dependent ATPase activity with IC50 values of between 7 and 15 muM. It also inhibits ATP-dependent Ca2+-uptake in a variety of microsomal membranes, although for cerebellar and platelet microsomes, a stimulation in Ca2+ uptake is observed at low curcumin concentrations (